| Absence of uvomorulin in a slowly compacting variant of H6 embryonal carcinoma cells. | |
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MedLine Citation:
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PMID: 2321096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When allowed to aggregate in calcium-containing medium, the H6 embryonal carcinoma cell variant named 6B(NG)C25 compacted more slowly than wild-type cells, and aggregates of hybrids between it and wild-type cells also compacted slowly, as if the variation (mutation) acted in a dominant fashion. In agreement with this, we now have found that the cell adhesion molecule uvomorulin is markedly reduced or absent in 6B(NG)C25 cells, as well as in the hybrids. A small amount of a higher-molecular-weight protein reacting with the antibody is present, which might represent residual uvomorulin migrating at a slower rate, an altered uvomorulin, the known precursor to uvomorulin, or an unrelated cross-reacting protein. |
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Authors:
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J W Littlefield; L L Whitehouse |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Somatic cell and molecular genetics Volume: 16 ISSN: 0740-7750 ISO Abbreviation: Somat. Cell Mol. Genet. Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-04-30 Completed Date: 1990-04-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8403568 Medline TA: Somat Cell Mol Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 191-4 Citation Subset: IM |
Affiliation:
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Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoradiography Cadherins / analysis*, metabolism Cell Line Electrophoresis, Polyacrylamide Gel Genetic Variation Humans Hybrid Cells / analysis, cytology, metabolism Immunoblotting Teratoma / analysis, genetics, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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CA 16754/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cadherins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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