| Absence of a significant extravascular contribution to the skeletal muscle BOLD effect at 3 T. | |
| | |
MedLine Citation:
|
PMID: 20665796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Blood oxygenation level dependent (BOLD) contrast in skeletal may reflect the contributions of both intravascular and extravascular relaxation effects. The purpose of this study was to determine the significance of the extravascular BOLD effect in skeletal muscle at 3 T. In experiments, R(2)* was measured before and during arterial occlusion under the following conditions: (1) the leg extended and rotated (to vary the capillary orientation with respect to the amplitude of static field) and (2) with the blood's signal nulled using a multiecho vascular space occupancy experiment. In the leg rotation protocol, 3 min of arterial occlusion decreased oxyhemoglobin saturation from 67% to 45% and increased R(2)* from 34.2 to 36.6 sec(-1), but there was no difference in the R(2)* response to occlusion between the extended and rotated positions. Numerical simulations of intra- and extravascular BOLD effects corresponding to these conditions predicted that the intravascular BOLD contribution to the R(2)* change was always > 50 times larger than the extravascular BOLD contribution. Blood signal nulling eliminated the change in R(2)* caused by arterial occlusion. These data indicate that under these experimental conditions, the contribution of the extravascular BOLD effect to skeletal muscle R(2)* was too small to be practically important. |
| | |
Authors:
|
Otto A Sanchez; Elizabeth A Copenhaver; Christopher P Elder; Bruce M Damon |
Related Documents
:
|
9669766 - Innervation of blood vessels in the rat incisor pulp: a scanning electron microscopic a... 9025216 - Regulation of vasomotion of arterioles and capillaries in the cat spinal cord: role of ... 11641356 - Estimating the size of the capillary-to-fiber interface in skeletal muscle: a compariso... 1416096 - Capillaries measured in canine diaphragm by two methods. 8983976 - Gap junctions are found between iris sphincter smooth muscle cells but not in the cilia... 7136856 - Motor endplate cholinesterase in human skeletal muscle. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-28 Completed Date: 2011-01-04 Revised Date: 2011-08-03 |
Medline Journal Info:
|
Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
|
Languages: eng Pagination: 527-35 Citation Subset: IM |
Affiliation:
|
Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Flow Velocity / physiology Collateral Circulation / physiology* Humans Magnetic Resonance Imaging / methods* Male Muscle, Skeletal / blood supply, physiology* Oxygen Consumption / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
AR050101/AR/NIAMS NIH HHS; M01 RR 00095/RR/NCRR NIH HHS; R01 AR050101-05/AR/NIAMS NIH HHS; UL1 RR024975/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 3D undersampled golden-radial phase encoding for DCE-MRA using inherently regularized iterative SENS...
Next Document: A technique for rapid single-echo spin-echo T2 mapping.