Document Detail

Absence of seizures despite high prevalence of epileptiform EEG abnormalities in children with autism monitored in a tertiary care center.
MedLine Citation:
PMID:  16499766     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Children with autism are commonly referred for video-EEG monitoring to determine the precise nature of their seizure-like events. METHODS: We studied 32 children with autism by using continuous video-EEG telemetry (VEEG) monitoring at a tertiary care referral center. RESULTS: Of the 32 total patients, 22 were primarily referred for seizure evaluation and 10 for 24-h interictal EEG recording. Studies in two additional patients were prematurely terminated because of intolerance (they are not included in the analyses). The median monitoring duration was 1 day (range, 1-7 days). Of 22 patients referred for seizure evaluation, 15 had recorded events, but none was an epileptic seizure; the other seven patients had no recorded events. Interictal epileptiform EEG abnormalities were detected in 19 (59%) of 32 patients. These abnormalities included focal sharp waves (in eight patients), multifocal sharp waves (in six patients), generalized spike-wave complexes (in 11 patients), and generalized paroxysmal fast activity/polyspikes (in two patients). Focal/multifocal and generalized epileptiform abnormalities coexisted in six patients. Notably, 11 (73%) of the 15 patients with nonepileptic events had interictal epileptiform EEG abnormalities. CONCLUSIONS: Video-EEG evaluation of children with autism reveals epileptiform EEG abnormalities in the majority. However, many recorded seizure-like events are not epileptic, even in children with epileptiform EEG abnormalities.
Howard L Kim; Joseph H Donnelly; Anne E Tournay; Teri M Book; Pauline Filipek
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  47     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2006-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  394-8     Citation Subset:  IM    
Department of Neurology, University of California at Irvine College of Medicine, UCI Medical Center, 101 The City Drive, Orange, CA 92868, U.S.A.
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MeSH Terms
Autistic Disorder / diagnosis*,  epidemiology,  physiopathology
California / epidemiology
Cerebral Cortex / physiopathology*
Child, Preschool
Diagnosis, Differential
Electroencephalography / methods,  statistics & numerical data*
Epilepsy / diagnosis*,  epidemiology,  physiopathology*
Hospitals, University / statistics & numerical data
Retrospective Studies
Seizures / diagnosis,  epidemiology*,  physiopathology
Telemetry / methods,  statistics & numerical data
Videotape Recording

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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