Document Detail


Absence of progestin receptors alters distribution of vasopressin fibers but not sexual differentiation of vasopressin system in mice.
MedLine Citation:
PMID:  18514427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perinatal estrogens increase the number of vasopressin-expressing cells and the density of vasopressin-immunoreactive fibers observed in adult male rodents. The mechanism of action of estrogens on sexual differentiation of the extra-hypothalamic vasopressin system is unknown. We hypothesized that the sexually dimorphic expression of progestin receptors (PRs) during development would masculinize vasopressin expression in mice. We compared the number of vasopressin-expressing cells in the bed nucleus of the stria terminalis (BNST) and medial amygdala and the density of vasopressin-immunoreactive fibers in several brain regions of male and female wild type and PRKO mice using in situ hybridization and immunohistochemistry. As expected, sex differences in vasopressin cell number were observed in the BNST and medial amygdaloid nucleus. Vasopressin-immunoreactive fiber density was sexually dimorphic in the lateral septum, lateral habenular nucleus, medial amygdaloid nucleus, and mediodorsal thalamus. Sex differences were also observed in the principal nucleus of the BNST and medial preoptic area but not in the dorsomedial hypothalamus, which are thought to receive vasopressin innervation from the suprachiasmatic nucleus. Deletion of PRs did not alter the sex difference in vasopressin mRNA expression and vasopressin fiber immunoreactivity in any area examined. However, deletion of PRs increased the density of vasopressin fiber immunoreactivity in the lateral habenular nucleus. Our data suggest that PRs modulate vasopressin levels, but not sexual differentiation of vasopressin innervation in mice.
Authors:
B D Rood; E K Murray; J Laroche; M K Yang; J D Blaustein; G J De Vries
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Neuroscience     Volume:  154     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-18     Completed Date:  2008-08-29     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  911-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Count
Drug Implants
Female
Immunohistochemistry
In Situ Hybridization
Male
Mice
Mice, Knockout
Nerve Fibers / physiology*
RNA, Messenger / biosynthesis,  genetics
Receptors, Progesterone / genetics,  physiology*
Sex Differentiation / drug effects,  physiology*
Silver Staining
Steroids / metabolism
Testosterone / administration & dosage,  pharmacology
Vasopressins / biosynthesis,  physiology*
Grant Support
ID/Acronym/Agency:
K02 MH001497/MH/NIMH NIH HHS; K02 MH001497-10/MH/NIMH NIH HHS; K02 MH01497/MH/NIMH NIH HHS; MH 067630/MH/NIMH NIH HHS; NS 19327/NS/NINDS NIH HHS; R01 MH047538/MH/NIMH NIH HHS; R01 MH047538-13/MH/NIMH NIH HHS; R01 MH47538/MH/NIMH NIH HHS; R01 NS019327/NS/NINDS NIH HHS; R01 NS019327-20/NS/NINDS NIH HHS; R21 MH067630/MH/NIMH NIH HHS; R21 MH067630-03/MH/NIMH NIH HHS; T32 MH47538/MH/NIMH NIH HHS; U54-HD28934/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Drug Implants; 0/RNA, Messenger; 0/Receptors, Progesterone; 0/Steroids; 11000-17-2/Vasopressins; 3XMK78S47O/Testosterone
Comments/Corrections

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