Document Detail


Absence of preferential glutamine uptake into neurons--an indication of a net transfer of TCA constituents from nerve endings to astrocytes?
MedLine Citation:
PMID:  7052419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uptake kinetics for glutamine were studied in several different neuronal preparations (perikarya prepared by gradient centrifugation, cultured cortical neurons, cultured, presumably glutamatergic cerebellar neurons, and brain prisms). In no case were any indications found of a high affinity uptake but a rather efficient low affinity uptake did occur. A similar, equally efficient low affinity uptake is, however, found in astrocytes. Thus, no preferential glutamine uptake occurs into neurons. It is, therefore, not likely that a net flow of glutamine takes place from astrocytes to neurons, compensating for the loss of TCA constituents when glutamate and GABA are released.
Authors:
L Hertz; A Yu; G Svenneby; E Kvamme; H Fosmark; A Schousboe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  16     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1983-06-17     Completed Date:  1983-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / metabolism*
Biological Transport
Brain / metabolism*
Cells, Cultured
Cerebellum / metabolism
Cerebral Cortex / metabolism
Glutamine / metabolism*
Kinetics
Mice
Mice, Inbred DBA
Neurons / metabolism*
Synaptosomes / metabolism
Tricarboxylic Acids / metabolism*
Chemical
Reg. No./Substance:
0/Tricarboxylic Acids; 56-85-9/Glutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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