Document Detail


Absence of phospholipase A2 activity in genital Mycoplasma hominis.
MedLine Citation:
PMID:  9773381     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical relevance of vaginal colonization with Mycoplasma hominis (M hominis) as a cause of prematurity is doubtful. One of the possible pathways which could explain the role of M hominis in the induction of preterm labour is an increased synthesis of prostaglandins by a phospholipase A2 activity. The aim of this study was to prove whether M hominis secrets proteins with a PLA2 activity and to test whether there are strain differences in the enzyme activity between M hominis isolated from women with normal pregnancy and those with preterm labour. Using specific radio-immunoassay we could not measure any PLA2 activity in the supernatant of all investigated M hominis strains. We exclude the mechanism of induction of preterm labour by M hominis via an increased prostaglandin synthesis. Our findings make a relation between vaginal colonization with M hominis and prematurity unlikely.
Authors:
T Walther; H Stepan; L Baumann; D Walther; R Faber
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  26     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-10     Completed Date:  1998-12-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  208-10     Citation Subset:  IM    
Affiliation:
Max-Delbrück-Center for Molecular Medicine Berlin-Buch, Germany. thowal@mdc-berlin.de
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MeSH Terms
Descriptor/Qualifier:
Female
Genital Diseases, Female / microbiology*
Humans
Mycoplasma hominis / enzymology*
Obstetric Labor, Premature / microbiology*
Phospholipases A / analysis*
Phospholipases A2
Pregnancy
Pregnancy Complications, Infectious / microbiology*
Species Specificity
Chemical
Reg. No./Substance:
EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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