Document Detail


Absence of perinatal transmission of blood-borne non-A, non-B hepatitis virus by chimpanzees with acute and chronic infection.
MedLine Citation:
PMID:  2566645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two chimpanzees were born to parents with chronic non-A, non-B hepatitis and remained with their mothers until 12 and 18 months, respectively. The infants were followed from 7 to 8 weeks of age with biweekly or monthly blood samples and with monthly liver biopsies from 4 to 7 months after birth. Another chimpanzee, along with both of its parents, was held throughout the parents' acute infection with non-A, non-B hepatitis; at this time the infant was 14-16 months of age, and it was followed with bi-weekly blood samples and monthly biopsies from the time of potential exposure for 20 months. No abnormalities indicative of non-A, non-B hepatitis were detected in these animals. During the 29 to 35 months of follow-up, alanine aminotransferases and gamma glutamyl-transferases (GGPT) levels remained well within normal range for animals held in the same facility. Histologic and electron microscopic examination of liver tissue revealed no abnormalities.
Authors:
B Brotman; W Boehle; A M Prince
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  28     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-07-07     Completed Date:  1989-07-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-5     Citation Subset:  IM    
Affiliation:
Vilab II, Liberian Institute for Biomedical Research, Robertsfield.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Alanine Transaminase / blood
Animals
Animals, Newborn
Biopsy
Chronic Disease
Disease Susceptibility
Female
Hepatitis C / pathology,  transmission*
Hepatitis Viruses / isolation & purification,  pathogenicity*
Hepatitis, Viral, Human / transmission*
Liver / microbiology,  pathology
Male
Maternal-Fetal Exchange
Pan troglodytes
Pregnancy
gamma-Glutamyltransferase / blood
Chemical
Reg. No./Substance:
EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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