Document Detail

Absence of oroticaciduria in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency.
MedLine Citation:
PMID:  108039     Owner:  NLM     Status:  MEDLINE    
Orotic acid excretion was normal when tested by three methods in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. These results do not support the speculation, based on the oroticaciduria observed by others, that the immunodeficiency in these disorders results from the inhibition of pyrimidine biosynthesis. An alternative hypothesis is discussed.
H A Simmonds; C F Potter; A Sahota; J S Cameron; D R Webster; D M Becroft
Related Documents :
3015969 - 3'-o-(4-benzoyl)benzoylcytidine 5'-triphosphate. a substrate and photoaffinity label fo...
22522019 - Feedstock mixture effects on sugar monomer recovery following dilute acid pretreatment ...
2411839 - Serine metabolism in rat embryos undergoing organogenesis.
20047309 - New nucleotide analogues with enhanced signal properties.
2833559 - Biosynthesis and scavenging of purines by pathogenic mycobacteria including mycobacteri...
567659 - Determination of orotic acid in whey and modified whey products.
22062469 - Effect of genetic rabbit lines on lipid content, lipolytic activities and fatty acid co...
8579359 - Stabilization of the tetrameric structure of human and bovine hemoglobins by pseudocros...
25186189 - A comparison of fruit quality parameters of wild bilberry (vaccinium myrtillus l.) grow...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  34     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  42-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Deaminase / deficiency*
Chromatography, Ion Exchange
Nucleoside Deaminases / deficiency*
Orotic Acid / urine*
Pentosyltransferases / deficiency*
Purine-Nucleoside Phosphorylase / deficiency*
Reg. No./Substance:
65-86-1/Orotic Acid; EC 2.4.2.-/Pentosyltransferases; EC Phosphorylase; EC 3.5.4.-/Nucleoside Deaminases; EC Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of zinc supplementation on plasma levels of vitamin A and retinol-binding protein in malnouri...
Next Document:  Circulating carcinoembryonic antigen immune complexes in sera of patients with carcinomata of the ga...