| Absence of oroticaciduria in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. | |
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MedLine Citation:
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PMID: 108039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Orotic acid excretion was normal when tested by three methods in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. These results do not support the speculation, based on the oroticaciduria observed by others, that the immunodeficiency in these disorders results from the inhibition of pyrimidine biosynthesis. An alternative hypothesis is discussed. |
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Authors:
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H A Simmonds; C F Potter; A Sahota; J S Cameron; D R Webster; D M Becroft |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 34 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1978 Oct |
Date Detail:
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Created Date: 1979-07-16 Completed Date: 1979-07-16 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 42-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Deaminase
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deficiency* Adult Child Chromatography, Ion Exchange Colorimetry Electrophoresis Humans Nucleoside Deaminases / deficiency* Orotic Acid / urine* Pentosyltransferases / deficiency* Purine-Nucleoside Phosphorylase / deficiency* |
| Chemical | |
Reg. No./Substance:
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65-86-1/Orotic Acid; EC 2.4.2.-/Pentosyltransferases; EC 2.4.2.1/Purine-Nucleoside Phosphorylase; EC 3.5.4.-/Nucleoside Deaminases; EC 3.5.4.4/Adenosine Deaminase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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