Document Detail

Absence of oroticaciduria in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency.
MedLine Citation:
PMID:  108039     Owner:  NLM     Status:  MEDLINE    
Orotic acid excretion was normal when tested by three methods in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. These results do not support the speculation, based on the oroticaciduria observed by others, that the immunodeficiency in these disorders results from the inhibition of pyrimidine biosynthesis. An alternative hypothesis is discussed.
H A Simmonds; C F Potter; A Sahota; J S Cameron; D R Webster; D M Becroft
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  34     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  42-5     Citation Subset:  IM    
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MeSH Terms
Adenosine Deaminase / deficiency*
Chromatography, Ion Exchange
Nucleoside Deaminases / deficiency*
Orotic Acid / urine*
Pentosyltransferases / deficiency*
Purine-Nucleoside Phosphorylase / deficiency*
Reg. No./Substance:
65-86-1/Orotic Acid; EC 2.4.2.-/Pentosyltransferases; EC Phosphorylase; EC 3.5.4.-/Nucleoside Deaminases; EC Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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