| Absence of neurotoxicity with medicinal grade terbutaline in the rat model. | |
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MedLine Citation:
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PMID: 21262341 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate neurological effects of terbutaline, rats were injected with saline, terbutaline (Sigma or American Pharmaceutical Partners (APP™)) at 0.5 mg/kg-d or 10 mg/kg-d between postnatal days (PND) 2-5 or 11-14. Brains collected 24 h after last injection were used to determine corpus-callosum thickness, Purkinje cell and neuronal number in the cerebellum. Ambulation, distance traveled, resting time and time on rotarod were analyzed. Terbutaline (both doses/grades at PND 11-14) decreased corpus-callosum thickness. Ambulation time was significantly decreased in the 10 mg/kg-d (Sigma) and 0.5 mg/kg-d of terbutaline (APP™) (PND 2-5) juvenile-rats and 10 mg/kg-d-Sigma adult-rats, 0.5 mg/kg-d APP™ (PND 11-14) adult-rats. Resting time was increased in both doses of APP™ (PND 2-5) in juvenile-rats, 10 mg/kg-d Sigma adult-rats. 10 mg/kg-d-Sigma (PND 2-5) decreased distance traveled in adult-rats. 0.5 mg/kg-d-Sigma (PND 2-5 and PND 11-14) decreased the time spent on rotarod (30 RPM) in adult-rats. Sigma terbutaline Sigma had 2× as much free base compared to APP™. In conclusion, APP™ terbutaline did not have a deleterious effect on the developing rat brain. |
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Authors:
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Michelle Y Owens; Kedra L Wallace; Naila Mamoon; Josephine Wyatt-Ashmead; William A Bennett |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-22 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 31 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-27 Completed Date: 2011-09-20 Revised Date: 2011-12-06 |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 447-53 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA. myowens@umsmed.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-2 Receptor Agonists
/
chemistry,
toxicity* Age Factors Aging Analysis of Variance Animals Animals, Newborn Behavior, Animal / drug effects Brain / drug effects*, growth & development, pathology, physiopathology Female Male Mass Spectrometry Motor Activity / drug effects Neurotoxicity Syndromes / etiology*, pathology, physiopathology Postural Balance / drug effects Rats Rats, Sprague-Dawley Terbutaline / chemistry, toxicity* Tocolytic Agents / chemistry, toxicity* |
| Grant Support | |
ID/Acronym/Agency:
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RR17701/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-2 Receptor Agonists; 0/Tocolytic Agents; 23031-25-6/Terbutaline |
| Comments/Corrections | |
Comment In:
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Reprod Toxicol. 2011 Nov;32(3):368-9; author reply 370-1
[PMID:
21708245
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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