Document Detail

Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice.
MedLine Citation:
PMID:  9002646     Owner:  NLM     Status:  MEDLINE    
Strategies of cell depletion were pursued to extend understanding of the functions of natural killer (NK) cell-like large granulated lymphocytes found in the rodent uterus during pregnancy. Repeated infusions of antibody to Ly-49G2, a surface marker thought to be expressed by the progenitor forms of these cells, removed Ly-49G2+ cells from the virgin but not the pregnant uterus. Large granulated uterine lymphocytes also differentiated during pregnancy in transgenic mice that carried a deletion in the IL-2 gene. This cell population was absent in two strains of mice, p56lck-/lck-.IL-2Rbeta-/IL-2Rbeta- and TgE26. Implantation sites in both of these strains had histopathological anomalies in the zone of decidualization. In TgE26 mice, a sudden onset of fetal loss began at Day 10 of gestation. Fetal death was associated with progressive changes in the maternal uterine arterioles, suggestive of localized arteriosclerosis associated with hypertension. TgE26 females carried immune-competent fetuses to term, apparently through preventive or compensatory mechanisms that may modify the uterine vasculature after the onset of vascular pathology. These studies are the first to suggest a vital role for large granulated lymphocytes in the promotion of fetal survival and pregnancy success.
M J Guimond; J A Luross; B Wang; C Terhorst; S Danial; B A Croy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of reproduction     Volume:  56     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-07-08     Completed Date:  1997-07-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  169-79     Citation Subset:  IM    
Department of Biomedical Sciences, University of Guelph, Ontario, Canada.
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MeSH Terms
Antibodies, Monoclonal / pharmacology
Embryo Implantation
Embryo Transfer
Fetal Resorption
Gene Deletion
Interleukin-2 / deficiency,  genetics
Killer Cells, Natural / immunology,  physiology*
Mice, Inbred C3H
Mice, Inbred CBA
Placenta / anatomy & histology
Pregnancy, Animal / physiology*
Uterus / blood supply,  cytology
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Interleukin-2

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