Document Detail

Absence of a lyso-PAF relationship with PAF (platelet activating factor) in monosodium urate crystal-induced inflammatory exudates.
MedLine Citation:
PMID:  2629894     Owner:  NLM     Status:  MEDLINE    
Monosodium urate crystal (MSU)-induced inflammation was evaluated for increased vascular permeability and platelet activating factor (PAF) production. Intraperitoneal injection of MSU crystals increased vascular permeability and lyso-PAF, as shown by acetylation and bioassay, but PAF was not detected. Intraperitoneal administration of PAF elicited dye-extravasation, which was abolished by the PAF antagonist WEB-2086, but this compound had no significant effect upon MSU-induced dye extravasation. Thus, the presence of lyso-PAF did not reflect in situ production of PAF. Lyso-PAF extracted from normal serum in amounts equivalent to that extravasated could account for the lyso-PAF observed. Thin-layer chromatographic analysis of acetylated extracts from plasma and peritoneal washouts showed identical Rf values to the PAF standard. We conclude that lyso-PAF in the exudate was associated with extravasated plasma proteins rather than a reflection of in situ production of PAF.
D E Griswold; L Hillegass; D Rotilio; S Mong; N Hanna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Eicosanoids     Volume:  2     ISSN:  0934-9820     ISO Abbreviation:  Eicosanoids     Publication Date:  1989  
Date Detail:
Created Date:  1990-05-01     Completed Date:  1990-05-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8906009     Medline TA:  Eicosanoids     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  151-6     Citation Subset:  IM    
Department of Immunology, SK&F Laboratories, Swedeland, PA 19479.
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MeSH Terms
Ascitic Fluid / pathology,  physiopathology
Capillary Permeability / physiology
Mice, Inbred BALB C
Peritonitis / chemically induced,  physiopathology*
Platelet Activating Factor / analogs & derivatives*,  physiology*
Uric Acid
Reg. No./Substance:
0/O-deacetyl platelet activating factor; 0/Platelet Activating Factor; 69-93-2/Uric Acid

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