| Absence of lung reactions after complement depletion during dialysis: an experimental study in pigs. | |
| | |
MedLine Citation:
|
PMID: 1741685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sequestration of 111In-labeled neutrophils (polymorphonuclear leukocytes--PMNs) in the lungs during sham dialysis was studied dynamically using a gamma camera. Five animals were pretreated with cobra venom factor, naja naja (CVF), to achieve depletion of the complement system, mainly C5a. Seven animals were studied without pretreatment with CVF. Central hemodynamics and gas exchange were studied as well as neutrophil function using luminescence and aggregation. In the control group there was a significant sequestration of neutrophils in the lungs, which reached a maximum between 15 and 17 min after the start of hemodialysis. The peripheral neutrophil count decreased concomitantly. These changes were virtually absent in the CVF-treated group. PMN aggregation and luminescence were abolished in CVF-treated animals. Both pulmonary artery pressure and pulmonary vascular resistance increased significantly in the control group, whereas in the CVF group these parameters remained unchanged. There were no differences in blood gases, platelet count, or hematocrit between the groups. The results clearly indicate that the activation of neutrophils within minutes after the start of hemodialysis is greatly dependent on C5a activation because it can be abolished by C5a depletion. This activation is accompanied by changes in the pulmonary circulation with increases in pressure and resistance. |
| | |
Authors:
|
S Blomquist; C Malmros; L Mårtensson; J Thörne |
Related Documents
:
|
3185305 - The influence of circulatory overload on extraalveolar microvessel endothelium of dog l... 171615 - Pulmonary pressure- volume relationships after corticotropin (acth) and salin injection... 7425695 - Lung water changes after thermal injury. the effects of crystalloid resuscitation and s... 3378965 - Prevention of abnormal pulmonary mechanics in the postmortem guinea pig lung. 3306205 - Vascular changes in hypertension. 10654495 - Arginine vasopressin in the treatment of 50 patients with postcardiotomy vasodilatory s... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Artificial organs Volume: 15 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 1991 Oct |
Date Detail:
|
Created Date: 1992-01-09 Completed Date: 1992-01-09 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 397-401 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, University Hospital, Lund, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cobra Venoms / pharmacology Complement C5a / deficiency*, physiology Hemodynamics / physiology Indium Radioisotopes / diagnostic use Lung / pathology*, radionuclide imaging Lymphocyte Activation / physiology Neutrophils / physiology* Pulmonary Gas Exchange / physiology Renal Dialysis* Swine |
| Chemical | |
Reg. No./Substance:
|
0/Cobra Venoms; 0/Indium Radioisotopes; 0/cobra venom factor; 80295-54-1/Complement C5a |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Elastic siloxane materials for endoprosthetic applications.
Next Document: Experimental study on the hemodynamic effects of veno-arterial extracorporeal membrane oxygenation w...