Document Detail

Absence of lung reactions after complement depletion during dialysis: an experimental study in pigs.
MedLine Citation:
PMID:  1741685     Owner:  NLM     Status:  MEDLINE    
Sequestration of 111In-labeled neutrophils (polymorphonuclear leukocytes--PMNs) in the lungs during sham dialysis was studied dynamically using a gamma camera. Five animals were pretreated with cobra venom factor, naja naja (CVF), to achieve depletion of the complement system, mainly C5a. Seven animals were studied without pretreatment with CVF. Central hemodynamics and gas exchange were studied as well as neutrophil function using luminescence and aggregation. In the control group there was a significant sequestration of neutrophils in the lungs, which reached a maximum between 15 and 17 min after the start of hemodialysis. The peripheral neutrophil count decreased concomitantly. These changes were virtually absent in the CVF-treated group. PMN aggregation and luminescence were abolished in CVF-treated animals. Both pulmonary artery pressure and pulmonary vascular resistance increased significantly in the control group, whereas in the CVF group these parameters remained unchanged. There were no differences in blood gases, platelet count, or hematocrit between the groups. The results clearly indicate that the activation of neutrophils within minutes after the start of hemodialysis is greatly dependent on C5a activation because it can be abolished by C5a depletion. This activation is accompanied by changes in the pulmonary circulation with increases in pressure and resistance.
S Blomquist; C Malmros; L Mårtensson; J Thörne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  15     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-01-09     Completed Date:  1992-01-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-401     Citation Subset:  IM    
Department of Anesthesiology, University Hospital, Lund, Sweden.
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MeSH Terms
Cobra Venoms / pharmacology
Complement C5a / deficiency*,  physiology
Hemodynamics / physiology
Indium Radioisotopes / diagnostic use
Lung / pathology*,  radionuclide imaging
Lymphocyte Activation / physiology
Neutrophils / physiology*
Pulmonary Gas Exchange / physiology
Renal Dialysis*
Reg. No./Substance:
0/Cobra Venoms; 0/Indium Radioisotopes; 0/cobra venom factor; 80295-54-1/Complement C5a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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