Document Detail


Absence of interaction between oxcarbazepine and erythromycin.
MedLine Citation:
PMID:  1414219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When erythromycin (ERY) is co-administrated with the antiepileptic carbamazepine (CBZ), a drug interaction may cause an increase in CBZ plasma concentrations, which can result in CBZ related toxic symptoms. This cross-over study was designated to investigate whether ERY influences the pharmacokinetics of the new antiepileptic oxcarbazepine (OXC) and its metabolites. In 8 healthy volunteers there were no significant differences in AUC, peak plasma concentrations or time to peak concentration when OXC was administered either with or without ERY. The results of this study suggest that OXC may offer an important advantage over CBZ especially when concomitant therapy with ERY is required.
Authors:
T Keränen; J Jolkkonen; P K Jensen; G P Menge; P Andersson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  86     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-29     Completed Date:  1992-10-29     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, University of Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticonvulsants / pharmacokinetics,  toxicity*
Carbamazepine / analogs & derivatives*,  pharmacokinetics,  toxicity
Dose-Response Relationship, Drug
Drug Interactions
Erythromycin / pharmacokinetics,  toxicity*
Female
Humans
Male
Metabolic Clearance Rate / drug effects
Chemical
Reg. No./Substance:
0/Anticonvulsants; 114-07-8/Erythromycin; 298-46-4/Carbamazepine; VZI5B1W380/oxcarbazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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