Document Detail

Absence of human bocavirus from deceased fetuses and their mothers.
MedLine Citation:
PMID:  20031484     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The human bocavirus (HBoV), a newly discovered parvovirus, is closely related to the bovine parvovirus and the canine minute virus, which are known to cause adverse pregnancy outcomes. Another human parvovirus, B19, can lead to fetal hydrops, miscarriage and intrauterine fetal death (IUFD). OBJECTIVES: To determine the prevalence of HBoV DNA in aborted fetuses and IUFDs. The HBoV serology of the mothers was also studied. STUDY DESIGN: We retrospectively studied all available fetuses (N=535) autopsied during 7/1992-12/1995, and 1/2003-12/2005 in Helsinki, Finland. All available formalin-fixed paraffin-embedded fetal tissues - placenta, heart and liver - of 120 miscarriages, 169 IUFDs, and 246 induced abortions were studied by quantitative PCR. We also measured the HBoV IgM and IgG antibodies in the corresponding maternal sera (N=462) mostly of the first trimester. The IgM-positive sera underwent HBoV PCR. RESULTS: None of the fetal tissues harbored HBoV DNA. A total of 97% (448/462) of the mothers were positive for IgG antibodies to HBoV, while only 0.9% (4/462) exhibited HBoV-specific IgM antibodies without viremia or respiratory symptoms. One IgM-positive mother had an unexplained fetal loss. CONCLUSIONS: We did not find HBoV DNA in any of the deceased fetuses. Almost all pregnant women were HBoV-IgG positive.
Anita Riipinen; Elina V?is?nen; Anne Lahtinen; Riitta Karikoski; Mika Nuutila; Helj?-Marja Surcel; Helena Taskinen; Klaus Hedman; Maria S?derlund-Venermo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-23
Journal Detail:
Title:  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology     Volume:  47     ISSN:  1873-5967     ISO Abbreviation:  J. Clin. Virol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815671     Medline TA:  J Clin Virol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  186-8     Citation Subset:  IM    
Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN-00250 Helsinki, Finland.
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MeSH Terms
Abortion, Spontaneous / etiology
Antibodies, Viral / blood
Fetal Death / etiology
Fetus / virology*
Finland / epidemiology
Heart / virology
Human bocavirus / isolation & purification*
Immunoglobulin G / blood
Immunoglobulin M / blood
Liver / virology
Middle Aged
Parvoviridae Infections / epidemiology*,  virology
Placenta / virology
Pregnancy Complications, Infectious / epidemiology*,  virology
Retrospective Studies
Young Adult
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M

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