Document Detail

Absence of hepatic uptake of Tc-99m sulfur colloid in an infant with Coxsackie B2 viral infection.
MedLine Citation:
PMID:  6307577     Owner:  NLM     Status:  MEDLINE    
After the intravenous administration of Tc-99m sulfur colloid, there was found homogeneous lung, renal, and splenic uptake with absence of uptake by the liver and bone marrow of a nine-day-old female infant. More than 20 other doses were dispensed from the same Tc-99m sulfur colloid preparation with the expected biodistribution. A necropsy done two days later showed diffuse hepatic hemorrhagic necrosis without evidence of intravascular fibrin deposition in the lungs or kidneys. The underlying cause of the infant's disease was a Coxsackie B2 viral infection, based upon positive postmortem viral cultures of kidney and liver tissues and characteristic histopathologic lesions of the central nervous system and viscera. The altered biodistribution presumably reflected marked impairment of Kupffer cell function and an apparent increase in pulmonary macrophages.
G H Hinkle; J C Leonard; H F Krous; J B Alexander
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  8     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  246-8     Citation Subset:  IM    
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MeSH Terms
Coxsackievirus Infections / radionuclide imaging*
Enterovirus B, Human
Hemorrhage / radionuclide imaging
Hepatitis, Viral, Human / radionuclide imaging*
Infant, Newborn
Infant, Newborn, Diseases / radionuclide imaging*
Liver / pathology
Liver Diseases / pathology,  radionuclide imaging*
Sulfur / diagnostic use
Technetium / diagnostic use
Technetium Tc 99m Sulfur Colloid
Reg. No./Substance:
0/Technetium Tc 99m Sulfur Colloid; 7440-26-8/Technetium; 7704-34-9/Sulfur

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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