| Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men. | |
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MedLine Citation:
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PMID: 14585088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We investigated the effect of an intensive training program on fasting leptin and adiponectin levels. METHODS: Sixteen middle-aged men with type 2 diabetes were randomly assigned to either a training or control group. The training program consisted of 8 weeks of supervised endurance exercise (75% VO(2peak), 45 min) twice a week, with intermittent exercise (five 2 min exercises at 85% VO(2peak) separated by 3 min exercises at 50% VO(2peak)) once a week, on an ergocycle. RESULTS: Training decreased abdominal fat by 44%, increased mid-thigh muscle cross-sectional area by 24%, and improved insulin sensitivity by 58% without significant change in body weight. Compared with controls, no significant variation in leptin or adiponectin levels was observed. However, in the trained group, change in adiponectin correlated with change in body weight (Spearman rank correlation, r(s):-0.76, P=0.03) but not with insulin sensitivity or abdominal adiposity variations. CONCLUSIONS: An 8 week intensive training program inducing a marked reduction in abdominal fat and increase in insulin sensitivity does not affect adiponectin and leptin levels in men with type 2 diabetes. |
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Authors:
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P Boudou; E Sobngwi; F Mauvais-Jarvis; P Vexiau; J-F Gautier |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 149 ISSN: 0804-4643 ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-30 Completed Date: 2004-01-08 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 421-4 Citation Subset: IM |
Affiliation:
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Department of Hormonal Biology, Saint-Louis University Hospital, Assistance Publique Hospitaux de Paris, Paris, France. philippe.boudou@sls.ap-hop-paris.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen Adiponectin Adipose Tissue / metabolism* Adult Diabetes Mellitus, Type 2 / metabolism*, physiopathology Exercise / physiology* Humans Insulin Resistance* Intercellular Signaling Peptides and Proteins* Leptin / metabolism Male Middle Aged Physical Endurance Proteins / metabolism* Weight Loss |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Intercellular Signaling Peptides and Proteins; 0/Leptin; 0/Proteins |
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