Document Detail


Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix.
MedLine Citation:
PMID:  9464737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the estrogen and progesterone receptor status of glassy cell carcinoma of the cervix to assess the possible implications of hormone replacement therapy in these patients. METHODS: The estrogen and progesterone receptor status of 13 glassy cell carcinomas was evaluated by immunohistochemistry using commercial monoclonal antibodies and a streptavidin-biotin detection system. RESULTS: No immunohistochemically detectable estrogen or progesterone receptor protein was present in tumor cells, although both receptors were identified in the adjacent normal cervical tissue. CONCLUSION: The absence of estrogen and progesterone receptors in glassy cell carcinoma suggests that this tumor would not be hormonally responsive and that these patients can be safely treated with hormone replacement therapy. Further studies are indicated to confirm this observation.
Authors:
I Atlas; W Gajewski; S Falkenberry; C O Granai; M M Steinhoff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  91     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-26     Completed Date:  1998-02-26     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  136-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology and Laboratory Medicine, Women and Infants' Hospital, Brown University, Providence, Rhode Island 02905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Carcinoma, Adenosquamous / drug therapy,  metabolism*,  pathology
Estrogen Replacement Therapy / standards*
Female
Humans
Immunohistochemistry
Middle Aged
Neoplasm Staging
Receptors, Estrogen / analysis*
Receptors, Progesterone / analysis*
Retrospective Studies
Uterine Cervical Neoplasms / drug therapy,  metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Receptors, Estrogen; 0/Receptors, Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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