Document Detail

Absence of effects of short-term estrogen replacement therapy on resting and exertional QT and QTc dispersion in postmenopausal women with coronary artery disease.
MedLine Citation:
PMID:  9825354     Owner:  NLM     Status:  MEDLINE    
Women, on average, have a longer QT interval on the electrocardiogram and are at higher risk of developing torsade de pointes from antiarrhythmic therapy than men. Although endogenous estrogen may play a role in these sex differences, the effect of estrogen replacement therapy has not been examined. Ten women, 65 +/- 7 years of age, with stable angina pectoris, positive exercise test, and angiographically proven coronary artery disease (at least one > or = 70%) stenosis were studied. All women had been postmenopausal for at least 1 year, and none had ever received hormone replacement therapy (HRT). The patients received standard dose HRT (0.625 mg/day oral conjugated estrogen) or matching placebo for 4 weeks in random order, with crossover after a 4-week washout period. Exercise testing using the standard Bruce protocol was performed at the end of the first and third months of the study. Antianginal medications remained unchanged throughout the study period. Compared to placebo, HRT caused a significant increase in plasma estradiol levels from 5.55 +/- 1.66 to 31.11 +/- 14.95 pg/mL (P = 0.001). QT and QTc, as well as QT and QTc dispersion, did not differ at rest and at peak exercise between the two exercise tests. Likewise, other test results, including angina score, exercise time, ST-T changes, blood pressure, heart rate, and double product were unchanged. Short-term HRT did not alter cardiac repolarization at rest and during exercise in postmenopausal women with known coronary disease.
E Sbarouni; E Zarvalis; Z S Kyriakides; D T Kremastinos
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  21     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-10     Completed Date:  1999-02-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2392-5     Citation Subset:  IM    
2nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.
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MeSH Terms
Coronary Disease / diagnosis,  physiopathology*
Cross-Over Studies
Electrocardiography / drug effects*
Estrogen Replacement Therapy*
Estrogens, Conjugated (USP) / therapeutic use
Exercise Test
Middle Aged
Time Factors
Reg. No./Substance:
0/Estrogens, Conjugated (USP)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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