Document Detail

Absence of decarboxylation of some aromatic-L-amino acids by cultured astrocytes.
MedLine Citation:
PMID:  3121134     Owner:  NLM     Status:  MEDLINE    
The addition of L-3,4-dihydroxyphenylalanine, L-5-hydroxytryptophan or m-tyrosine to cultured isolated astrocytes does not elicit the synthesis of either dopamine, 5-hydroxytryptamine or m-tyramine, respectively. In contrast, the astrocytes show ability to take up and store dopamine and 5-hydroxytryptamine that are in turn respectively metabolized to 3,4-dihydroxyphenylacetic acid or 5-hydroxyindoleacetic acid. These findings suggest that astroglial cell cultures lack aromatic-L-amino acid decarboxylase and give further evidence that these cells contain monoamine oxidase.
A V Juorio; W Walz; B D Sloley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  426     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-01-25     Completed Date:  1988-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  183-6     Citation Subset:  IM    
Psychiatric Research Division, Saskatchewan Health, Saskatoon, Canada.
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MeSH Terms
5-Hydroxytryptophan / metabolism
Amino Acids / metabolism*
Astrocytes / metabolism*
Cells, Cultured
Dihydroxyphenylalanine / metabolism
Dopamine / metabolism
Serotonin / metabolism
Tyramine / metabolism
Reg. No./Substance:
0/Amino Acids; 50-67-9/Serotonin; 51-67-2/Tyramine; 56-69-9/5-Hydroxytryptophan; 588-05-6/3-tyramine; 63-84-3/Dihydroxyphenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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