Document Detail

Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DR beta.
MedLine Citation:
PMID:  1975853     Owner:  NLM     Status:  MEDLINE    
To test the possibility that maternally expressed susceptibility genes for pre-eclampsia/eclampsia are closely linked to the HLA region on chromosome 6 of the human genome, members of ten pedigrees with multiple cases of these disorders were typed for HLA DR beta restriction fragment length polymorphisms by means of TaqI digests. The data were analysed by the LIPED program to calculate lod scores, by several programs to detect potential heterogeneity of recombination fraction between pedigrees, and by the affected-sibling and the affected-pedigree-member methods. The results exclude close linkage. If the putative susceptibility genes lie on chromosome 6 they must lie at least 5 centiMorgans, and probably more, from the HLA DR beta loci. No indication of linkage at higher recombination fractions was found. The main maternally expressed genes affecting susceptibility to pre-eclampsia are not in the HLA region.
A N Wilton; D W Cooper; S P Brennecke; S M Bishop; P Marshall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  336     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-12     Completed Date:  1990-10-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  653-7     Citation Subset:  AIM; IM    
School of Biological Sciences, Macquarie University, New South Wales, Australia.
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MeSH Terms
Chromosome Mapping*
Chromosomes, Human, Pair 6*
Disease Susceptibility
Eclampsia / genetics*
Electrophoresis, Agar Gel
Evaluation Studies as Topic
Genetic Markers / blood
HLA-DR Antigens / genetics*
Heterozygote Detection / methods*
Linkage (Genetics)*
Lod Score
Polymorphism, Restriction Fragment Length
Pre-Eclampsia / genetics
Recombination, Genetic
Reg. No./Substance:
0/Genetic Markers; 0/HLA-DR Antigens
Comment In:
Lancet. 1990 Nov 24;336(8726):1319-20   [PMID:  1978142 ]

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