Document Detail

Absence of beta-adrenergic receptor involvement in cerebrovascular dilation by halothane in monkeys.
MedLine Citation:
PMID:  3026207     Owner:  NLM     Status:  MEDLINE    
We determined, in monkeys, whether halothane-induced cerebrovascular dilation is mediated by beta-adrenergic receptors and whether cerebrovascular tone progressively returns to baseline values during prolonged halothane anesthesia. Total cerebral blood flow (CBF), cerebral perfusion pressure, plasma halothane concentration, and arterial blood gas tensions and pH were measured in 14 rhesus monkeys mechanically ventilated with 0.5% (inspired) halothane, 33% O2 and balance N2O. Halothane was increased to 2.0% and the measurements repeated 30 and 60 min later. Then either 0.9% NaCl (controls n = 6) or propranolol (n = 8), 1.0 mg/kg was infused intravenously over 10 min, and the measurements repeated at 70, 90, 120, and 150 min. After 30 min at 2.0% halothane, CBF increased in the controls by 50% (P less than 0.05) from 92 +/- 8 (mean +/- SD) to 137 +/- 39 ml X 100 g-1 X min-1 and in the propranolol group by 30% (P less than 0.05) from 106 +/- 33 to 137 +/- 28 ml X 100 g-1 X min-1. After 2.5 hr of 2.0% halothane anesthesia, CBF remained elevated above baseline levels, but by only 28 and 23% in the control and propranolol groups, respectively. Cerebrovascular resistance was identical in both groups (0.55 +/- 0.33 vs 0.53 +/- 0.13 mm Hg X ml-1 X 100 g 1 X min 1). The results show that there is only a 10-20% return of CBF toward baseline levels after up to 2.5 hr of 2% halothane anesthesia. The results also indicate that halothane-induced cerebrovascular dilation is not mediated by beta-adrenergic receptors.
P H Nikki; E M Nemoto; A L Bleyaert; F H Taylor; P M Winter
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  66     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-03     Completed Date:  1987-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Carbon Dioxide / blood
Cerebrovascular Circulation / drug effects*
Halothane / administration & dosage,  blood,  pharmacology*
Hydrogen-Ion Concentration
Infusions, Intravenous
Intracranial Pressure / drug effects
Macaca mulatta
Oxygen / blood
Propranolol / administration & dosage,  pharmacology
Receptors, Adrenergic, beta / physiology*
Vascular Resistance / drug effects
Vasodilation / drug effects*
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 124-38-9/Carbon Dioxide; 151-67-7/Halothane; 525-66-6/Propranolol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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