| Absence of anti-BP180 antibodies in mothers of infants with bullous pemphigoid. | |
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MedLine Citation:
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PMID: 16634883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is not clear whether bullous pemphigoid (BP) of infancy is linked to maternal transmission of pathogenic autoantibodies. Objectives To search for anti-BP180 antibodies in the sera of infants with BP and their mothers, using sensitive and specific methods. METHODS: Four infants (<6 months) with BP and their mothers were tested for anti-BP180 antibodies by indirect immunofluorescence, immunoblotting and enzyme-linked immunosorbent assay (ELISA). RESULTS: We found anti-BP180 antibodies in the sera of the four infants with all methods. These antibodies reacted with the extracellular domain NC16A. In the serum of their mothers we found 180 and 160 kDa proteins, each in one case, but indirect immunofluorescence and ELISA were negative, suggesting the absence of anti-BP180 autoantibodies reacting with the extracellular domain NC16A. CONCLUSIONS: BP of infants is not due to maternofetal transmission of pathogenic autoantibodies. Other hypotheses for the pathophysiology of BP are discussed. |
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Authors:
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C Chiavérini; D Hamel-Teillac; D Gilbert; Y Prost |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of dermatology Volume: 154 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-25 Completed Date: 2006-08-31 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 839-43 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Hospital Necker-Enfants Malades, Paris, and Clinical and Experimental Immunology Laboratory, University of Medicine, Rouen, France. christine.chiaverini@free.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / blood* Autoantigens / immunology* Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique, Indirect Humans Infant Male Maternal-Fetal Exchange / immunology Non-Fibrillar Collagens Pemphigoid, Bullous / embryology, immunology*, pathology Pregnancy Skin / immunology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Autoantigens; 0/Non-Fibrillar Collagens; 0/collagen type XVII |
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