| Absence of anaplastic lymphoma kinase (ALK) and Epstein-Barr virus gene products in primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis. | |
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MedLine Citation:
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PMID: 9415224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevalence of the t(2;5)(p23;q35) and/or anaplastic lymphoma kinase (ALK) gene products in cutaneous anaplastic large cell (ALC) lymphomas and a potential precursor lesion, lymphomatoid papulosis (LyP), is controversial. ALK gene products, which are absent from normal lymphohaematopoietic cells, are a phenotypic marker of lymphomas carrying the t(2;5). We used in situ hybridization and immunohistology to screen 14 cutaneous ALC lymphomas, 21 cases of LyP, and one nodal ALC lymphoma associated with LyP for ALK gene products. ALK gene products were not detectable in these cases. In contrast, ALK gene products were found in a lymphonodal ALC lymphoma with subsequent extension to the skin and in t(2;5)-positive cell lines. Detection of the Epstein-Barr virus (EBV)-encoded small nuclear transcripts (EBER), and of immunoglobulin light chain transcripts served to check for the presence of cellular RNA in the tissue sections. EBER transcripts were found in scattered reactive lymphoid cells, but not in atypical or tumour cells. ALK gene expression and EBV infection seem to be a rare finding in cutaneous ALC lymphomas and LyP. This points to a molecular aetiology of primary cutaneous ALC lymphomas and LyP distinct from that of extracutaneous CD30+ lymphoproliferative disease. Detection of the t(2;5) or ALK gene products in cutaneous lymphoproliferative lesions therefore requires exclusion of extracutaneous ALC lymphoma in such patients. |
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Authors:
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H Herbst; C Sander; M Tronnier; H Kutzner; H Hügel; P Kaudewitz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of dermatology Volume: 137 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-01-13 Completed Date: 1998-01-13 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 680-6 Citation Subset: IM |
Affiliation:
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Institut für Pathologie, Universitätsklinikum Benjamin Franklin, Freie Universität, Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Immunoglobulin kappa-Chains / analysis In Situ Hybridization Lymphoma, Large-Cell, Anaplastic / enzymology*, virology Lymphomatoid Papulosis / enzymology*, virology Protein-Tyrosine Kinases / genetics, metabolism* RNA Probes RNA, Neoplasm / analysis RNA, Viral / analysis RNA-Binding Proteins / analysis Ribosomal Proteins* Skin Neoplasms / enzymology*, virology Tumor Cells, Cultured Tumor Markers, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin kappa-Chains; 0/RNA Probes; 0/RNA, Neoplasm; 0/RNA, Viral; 0/RNA-Binding Proteins; 0/Ribosomal Proteins; 0/Tumor Markers, Biological; 135844-68-7/RPL22 protein, human; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.1/anaplastic lymphoma kinase |
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