Document Detail

Absence Of Oxysterol-like Side Effects in Human Monocytic Cells treated with Phytosterols and Oxyphytosterols.
MedLine Citation:
PMID:  22490085     Owner:  NLM     Status:  Publisher    
Oxysterols, found in some commonly consumed foods, can induce a wide range of cytotoxic effects, which have been extensively studied. On the other hand, the side effects of phytosterols and oxyphytosterols, are less well known. Over the past few years, different types of food have been enriched with phytosterols based on the properties of these compounds that reduce circulating cholesterol levels in certain experimental conditions. It is therefore important to gain better knowledge of the risks and benefits of this type of diet. In this study, conducted in human monocytic U937 cells, the ability of phytosterols (sitosterol, campesterol) and oxyphytosterols (7β-hydroxysitosterol, 7-ketositosterol) to induce cell death, polar lipid accumulation, and pro-inflammatory cytokine (MCP-1; IL-8) secretion was determined and compared to oxysterols (7-ketocholesterol, 7β-hydroxycholesterol). Phytosterols and oxyphytosterols had no significant effects on the parameters studied; only 7β-hydroxysitosterol slightly increased cell death, whereas at the concentration used (20 µg/mL), strong cytotoxic effects were observed with the oxysterols. With sitosterol, campesterol, and 7-ketositosterol, IL-8 secretion was decreased, and with campesterol the intracellular polar lipid level was reduced. Our data show that phytosterols and oxyphytosterols have no oxysterol-like side effects and they rather argue in favor of phytosterols beneficial effects.
Anne Vejux; Thomas Montange; Lucy Martine; Amira Zarrouk; Jean-Marc Riedinger; Gérard Lizard
Related Documents :
16732365 - Determining 234th and 238u in rocks, soils, and sediments via the doublet gamma at 92.5...
15744605 - Fabrication of hydroxyapatite ceramics with controlled pore characteristics by slip cas...
22482725 - G-protein-coupled receptors in intestinal chemosensation.
1310305 - The gamma contamination food factor.
1427515 - Effects of phenolic smoke condensates and their components on hepatic drug metabolizing...
15724705 - A one-year intensified study of outbreaks of gastroenteritis in the netherlands.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-10
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Design of high-performance parallelized gene predictors in MATLAB.
Next Document:  Exposures to fine particulate air pollution and respiratory outcomes in adults using two national da...