| Absence of the JAK2 mutation V617F in CD34+ hematopoietic stem and progenitor cells from patients with BCR-ABL-positive CML in chronic phase and blast crisis. | |
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MedLine Citation:
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PMID: 16442619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we examined highly enriched CD34+ cells from patients with BCR-ABL-positve CML in chronic phase or blast crisis for the JAK2 V617F activation mutation by sequencing. The cells examined did not bear the mutation irrespective of the disease stage. This finding suggests that the previously described increase of expression and kinase activity of JAK2 in CML cells does not result from the JAK2 V617F activation mutation and that transformation into blast crisis is not associated with the occurrence of this mutation. |
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Authors:
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Ralf Kronenwett; Thorsten Gräf; Frank Neumann; Sabrina Pechtel; Ulrich Steidl; Elena Diaz-Blanco; Rainer Haas |
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Publication Detail:
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Type: Letter; Research Support, Non-U.S. Gov't Date: 2006-01-26 |
Journal Detail:
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Title: Leukemia research Volume: 30 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-08-21 Completed Date: 2006-11-08 Revised Date: 2012-06-05 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 1323-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Substitution Antigens, CD / blood Antigens, CD34 / blood Blast Crisis DNA Primers Hematopoietic Stem Cells / pathology Humans Janus Kinase 2 Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*, pathology Mutation Polymerase Chain Reaction Protein-Tyrosine Kinases / genetics* Proto-Oncogene Proteins / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD34; 0/DNA Primers; 0/Proto-Oncogene Proteins; EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.2/JAK2 protein, human |
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