Document Detail


Absence of gastrointestinal pathogens in ileum tissue resected for necrotizing enterocolitis.
MedLine Citation:
PMID:  22173144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in premature infants and has been linked with viral antigens in as much as 40% of cases in single-center cohorts. We examined 28 tissue sections from surgically resected ileum from 27 preterm infants with NEC from 2 separate institutions for 15 common bacterial, viral, and parasitic gastrointestinal pathogens using multiplex reverse transcriptase polymerase chain reaction amplification and suspension array detection methods. We did not detect infectious enteritis pathogens in any of the NEC tissues and conclude that gastrointestinal pathogens are a rare cause of NEC.
Authors:
Tim Ullrich; Yi-Wei Tang; Hernan Correa; Steven A Garzon; Akhil Maheshwari; Melissa Hill; Pranathi Matta; Mohan K Krishnan; Jörn-Hendrik Weitkamp
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  31     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-15     Completed Date:  2012-07-16     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / isolation & purification*
Enterocolitis, Necrotizing / microbiology*
Female
Humans
Ileum / microbiology*,  parasitology,  virology*
Infant
Infant, Newborn
Male
Multiplex Polymerase Chain Reaction
Parasites / isolation & purification*
Reverse Transcriptase Polymerase Chain Reaction
Viruses / isolation & purification*
Grant Support
ID/Acronym/Agency:
K08 HD061607/HD/NICHD NIH HHS; K08 HD061607-01/HD/NICHD NIH HHS; K08HD061607/HD/NICHD NIH HHS; KL2 RR024977/RR/NCRR NIH HHS; KL2 TR000446/TR/NCATS NIH HHS; R01 HD059142/HD/NICHD NIH HHS; R01 HD059142-01/HD/NICHD NIH HHS; R01HD059142/HD/NICHD NIH HHS; TL1 RR024978/RR/NCRR NIH HHS; TL1 TR000447/TR/NCATS NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 RR024975-01/RR/NCRR NIH HHS; UL1 RR024975-01/RR/NCRR NIH HHS; UL1 TR000445/TR/NCATS NIH HHS
Comments/Corrections

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