| Absence of CCL2 is sufficient to restore hippocampal neurogenesis following cranial irradiation. | |
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MedLine Citation:
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PMID: 23041279 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cranial irradiation for the treatment of brain tumors causes a delayed and progressive cognitive decline that is pronounced in young patients. Dysregulation of neural stem and progenitor cells is thought to contribute to these effects by altering early childhood brain development. Earlier work has shown that irradiation creates a chronic neuroinflammatory state that severely and selectively impairs postnatal and adult neurogenesis. Here we show that irradiation induces a transient non-classical cytokine response with selective upregulation of CCL2/monocyte chemoattractant protein-1(MCP-1). Absence of CCL2 signaling in the hours after irradiation is alone sufficient to attenuate chronic microglia activation and allow the recovery of neurogenesis in the weeks following irradiation. This identifies CCL2 signaling as a potential clinical target for moderating the long-term defects in neural stem cell function following cranial radiation in children. |
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Authors:
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Star W Lee; Ursula Haditsch; Branden J Cord; Raphael Guzman; Soo Jeong Kim; Chotima Boettcher; Josef Priller; Brandi K Ormerod; Theo D Palmer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-3 |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: - ISSN: 1090-2139 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Stanford University, Institute for Stem Cell Biology and Regenerative Medicine, Stanford, CA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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