Document Detail


Absence of CCL2 is sufficient to restore hippocampal neurogenesis following cranial irradiation.
MedLine Citation:
PMID:  23041279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cranial irradiation for the treatment of brain tumors causes a delayed and progressive cognitive decline that is pronounced in young patients. Dysregulation of neural stem and progenitor cells is thought to contribute to these effects by altering early childhood brain development. Earlier work has shown that irradiation creates a chronic neuroinflammatory state that severely and selectively impairs postnatal and adult neurogenesis. Here we show that irradiation induces a transient non-classical cytokine response with selective upregulation of CCL2/monocyte chemoattractant protein-1 (MCP-1). Absence of CCL2 signaling in the hours after irradiation is alone sufficient to attenuate chronic microglia activation and allow the recovery of neurogenesis in the weeks following irradiation. This identifies CCL2 signaling as a potential clinical target for moderating the long-term defects in neural stem cell function following cranial radiation in children.
Authors:
Star W Lee; Ursula Haditsch; Branden J Cord; Raphael Guzman; Soo Jeong Kim; Chotima Boettcher; Josef Priller; Brandi K Ormerod; Theo D Palmer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-03
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  30     ISSN:  1090-2139     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-30     Completed Date:  2013-10-22     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Chemokine CCL2 / genetics,  metabolism*
Cranial Irradiation*
Hippocampus / cytology*,  metabolism,  radiation effects
Male
Mice
Mice, Knockout
Microglia / cytology,  metabolism,  radiation effects
Neural Stem Cells / cytology,  metabolism,  radiation effects
Neurogenesis / physiology*,  radiation effects
Neurons / cytology*,  metabolism,  radiation effects
Grant Support
ID/Acronym/Agency:
F30 NS04696701/NS/NINDS NIH HHS; R01 MH071472/MH/NIMH NIH HHS; R01 MH071472/MH/NIMH NIH HHS; R01 MH085911/MH/NIMH NIH HHS; R01 NS045113/NS/NINDS NIH HHS; R01NS045113-02/NS/NINDS NIH HHS; T32 MH020016/MH/NIMH NIH HHS; T32GM0076365/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Chemokine CCL2
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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