Document Detail

Absence of Bcl-2 expression favors response to the short-term administration of diethylstilbestrol diphosphate in prostate Cancer.
MedLine Citation:
PMID:  16998806     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neoadjuvant hormone therapy remains a controversial issue in spite of multiple studies having been performed. METHODS: We performed short-term (10 days) treatment with diethylstilbestrol (DES) in 30 patients with stages T2 or T3 prostate cancer (PCa). All the patients underwent needle core prostate biopsy before and radical prostatectomy within a month after the start of the endocrine therapy. The histological effects in PCa and the changes in morphological and clinical parameters and their association were elucidated. RESULTS: Serum PSA (P < 0.001), Ki-67 PI (P = 0.022), and AR (P = 0.002) expression decreased after the treatment. An obvious effect (Grade 1-3) of endocrine treatment was seen in 11 of 30 patients and was associated with a prominent PSA decrease (P = 0.0274) and with older age (P = 0.0026). Pre-treatment specimens from a group without any effects of endocrine therapy had a higher frequency of Bcl-2 positivity (57.9%) compared to the group of Grade 1-3 effects (27.3%). Prostatectomy specimens presented with significantly higher AI in Bcl-2 negative cases (P = 0.0029) and pre treatment Bcl-2 was associated with a higher AI in Grade 1-3 patients (P = 0.0393). CONCLUSIONS: Older age is a predictor of histological effects in short-term hormone treatment of PCa. A lower Bcl-2 in biopsy specimens presented more frequently in the patients who experienced a prominent effect of endocrine therapy, and it was also useful to predict a significantly higher AI in Grade 1-3 patients. Histological effects are also associated with the PSA decrease, reflecting the clinically meaningful shrinkage of tumors and a decrease of tumor burden.
Akira Nagaoka; Yoko Kubota; Seiichi Kurosu; Teruhiro Nakada; Vladimir Bilim; Yosihiko Tomita; Teiichi Motoyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Prostate     Volume:  66     ISSN:  0270-4137     ISO Abbreviation:  Prostate     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-01     Completed Date:  2007-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8101368     Medline TA:  Prostate     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1779-87     Citation Subset:  IM    
Department of Urology, Yamagata University School of Medicine, Yamagata, Japan.
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MeSH Terms
Antineoplastic Agents, Hormonal / administration & dosage*
Apoptosis / drug effects
Diethylstilbestrol / administration & dosage,  analogs & derivatives*
Drug Administration Schedule
In Situ Nick-End Labeling
Ki-67 Antigen / biosynthesis
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Prostate-Specific Antigen / blood
Prostatic Neoplasms / drug therapy*,  metabolism,  pathology,  surgery
Proto-Oncogene Proteins c-bcl-2 / biosynthesis*,  deficiency
Receptors, Androgen / biosynthesis
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 0/Ki-67 Antigen; 0/Proto-Oncogene Proteins c-bcl-2; 0/Receptors, Androgen; 13425-53-1/fosfestrol; 56-53-1/Diethylstilbestrol; EC Antigen

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