| Absence of BRAF mutation in pediatric and adolescent germ cell tumors indicate biological differences to adult tumors. | |
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MedLine Citation:
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PMID: 22147429 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The V600E mutation of the BRAF gene has been reported to be associated with poor prognosis of germ cell tumors in adult patients. We analyzed the mutational status of the BRAF and KRAS gene as well as MLH1 and MSH6 expression as surrogate markers for microsatellite instability in 70 pediatric germ cell tumors. Neither BRAF and KRAS mutations nor loss of MLH1 and MSH6 expression were found. Our data provide further evidence for patient age related biological differences in germ cell tumors and demonstrate that prognostic biomarkers cannot necessarily be transferred from one age group to the other. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. |
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Authors:
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Neus Masqué-Soler; Monika Szczepanowski; Ivo Leuschner; Christian Vokuhl; Jochen Haag; Gabriele Calaminus; Wolfram Klapper |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-6 |
Journal Detail:
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Title: Pediatric blood & cancer Volume: - ISSN: 1545-5017 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel, Kiel, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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