| Absence of the BRAF and the GRIM-19 mutations in oncocytic (Hürthle cell) solid cell nests of the thyroid. | |
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MedLine Citation:
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PMID: 22431538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the first case of oncocytic solid cell nests (SCNs), found in the right lobe of the thyroid of a 70-year-old man. Conventional SCNs and 1 papillary microcarcinoma (mPTC) were also found in the left lobe. In the oncocytic SCNs, 80% of the main cells showed oncocytic cytoplasm immunoreactive for porin and proteins of the SDHB and SDHA genes. Positivity for cytokeratin 19, p63, galectin-3, and HBME-1 and negativity for thyroglobulin, thyroperoxidase, vimentin, Oct-4, and α-fetoprotein were found in oncocytic and conventional SCNs. An inverse correlation was found between oncocytic metaplasia and p63. Association with C cells was confirmed at protein and messenger RNA levels in both types of SCNs. No germinal mutation of GRIM-19 was detected. No somatic BRAF mutation was found in any of the SCNs nor in the mPTC. We conclude that SCNs may acquire mitochondrial alterations similar to those seen in follicular and C cells, as well as in their respective tumors. |
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Authors:
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José Cameselle-Teijeiro; Rute Ferreira; Nuria Caramés; Ihab Abdulkader; Valdemar Máximo; Paula Soares; Manuel Sobrinho-Simões |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of clinical pathology Volume: 137 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-20 Completed Date: 2012-05-04 Revised Date: 2012-06-21 |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 612-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Clinical University Hospital, SERGAS, Santiago de Compostela, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Apoptosis Regulatory Proteins / genetics*, metabolism Carcinoma, Papillary / genetics*, metabolism, pathology Humans Male Mutation NADH, NADPH Oxidoreductases / genetics*, metabolism Proto-Oncogene Proteins B-raf / genetics*, metabolism Thyroid Gland / metabolism, pathology* Thyroid Neoplasms / genetics*, metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Apoptosis Regulatory Proteins; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 1.6.5.-/GRIM19 protein, human; EC 2.7.11.1/BRAF protein, human; EC 2.7.11.1/Proto-Oncogene Proteins B-raf |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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