Document Detail

Absence of the BRAF and the GRIM-19 mutations in oncocytic (Hürthle cell) solid cell nests of the thyroid.
MedLine Citation:
PMID:  22431538     Owner:  NLM     Status:  MEDLINE    
We report the first case of oncocytic solid cell nests (SCNs), found in the right lobe of the thyroid of a 70-year-old man. Conventional SCNs and 1 papillary microcarcinoma (mPTC) were also found in the left lobe. In the oncocytic SCNs, 80% of the main cells showed oncocytic cytoplasm immunoreactive for porin and proteins of the SDHB and SDHA genes. Positivity for cytokeratin 19, p63, galectin-3, and HBME-1 and negativity for thyroglobulin, thyroperoxidase, vimentin, Oct-4, and α-fetoprotein were found in oncocytic and conventional SCNs. An inverse correlation was found between oncocytic metaplasia and p63. Association with C cells was confirmed at protein and messenger RNA levels in both types of SCNs. No germinal mutation of GRIM-19 was detected. No somatic BRAF mutation was found in any of the SCNs nor in the mPTC. We conclude that SCNs may acquire mitochondrial alterations similar to those seen in follicular and C cells, as well as in their respective tumors.
José Cameselle-Teijeiro; Rute Ferreira; Nuria Caramés; Ihab Abdulkader; Valdemar Máximo; Paula Soares; Manuel Sobrinho-Simões
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  137     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-20     Completed Date:  2012-05-04     Revised Date:  2012-06-21    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  612-8     Citation Subset:  AIM; IM    
Department of Pathology, Clinical University Hospital, SERGAS, Santiago de Compostela, Spain.
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MeSH Terms
Apoptosis Regulatory Proteins / genetics*,  metabolism
Carcinoma, Papillary / genetics*,  metabolism,  pathology
NADH, NADPH Oxidoreductases / genetics*,  metabolism
Proto-Oncogene Proteins B-raf / genetics*,  metabolism
Thyroid Gland / metabolism,  pathology*
Thyroid Neoplasms / genetics*,  metabolism,  pathology
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 1.6.5.-/GRIM19 protein, human; EC protein, human; EC Proteins B-raf

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