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Absence Of Airway Secretion Accumulation Predicts Tolerance To Noninvasive Ventilation In Als.
MedLine Citation:
PMID:  23322888     Owner:  NLM     Status:  Publisher    
BACKGROUND:This study aimed to assess factors which predict good tolerance of noninvasive ventilation (NIV), in order to improve survival and quality of life in amyotrophic lateral sclerosis (ALS) patients.METHODS:We conducted a prospective study on ALS patients requiring NIV. The study's primary endpoint was NIV tolerance at one month. Patients, several of whom failed to complete the study, were classified as 'tolerant' or 'poorly tolerant' according to the number of hours of NIV use (more or less than 4 hours per night, respectively).RESULTS:81 patients, 73 of whom also attended the one-month follow-up visit, participated over 34 months. NIV tolerance after the first day of utilisation predicted tolerance at 1 month (77.6 % and 75.3 % of patients, respectively). Multivariate analysis disclosed three factors predicting good NIV tolerance: 1° absence of airway secretion accumulation prior to NIV onset (odds ratio, OR=11.5); 2° normal bulbar function at initiation of NIV (OR= 8.5) and 3° older age (weakly significant, OR=1.1).CONCLUSION:Our study reveals three factors which are predictive of good NIV tolerance, in particular the absence of airway secretion accumulation, which should prompt NIV initiation before its appearance.
Nadia Vandenberghe; Anne-Evelyne Vallet; Thierry Petitjean; Pierre Le Cam; Stéphane Peysson; Claude Guerin; Frédéric Dailler; Sylvie Jay; Vincent Cadiergue; Françoise Bouhour; Isabelle Court-Fortune; Jean-Philippe Camdessanche; Jean-Christophe Antoine; François Philit; Pascal Beuret; Sylvie Bin-Dorel; Christophe Vial; Emmanuel Broussolle
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Respiratory care     Volume:  -     ISSN:  0020-1324     ISO Abbreviation:  Respir Care     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Hospices Civils de Lyon, Centre SLA de Lyon (Service d'Electroneuromyographie et Service de Neurologie C), Hôpital Neurologique Pierre Wertheimer, Lyon, France.
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