| Abruptio placentae in the baboon (Papio spp.). | |
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MedLine Citation:
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PMID: 22265925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Placental abruption is a serious condition that increases perinatal morbidity and mortality. Clinical prevention and treatment options are limited, especially in human preterm deliveries. Knowledge of the mechanisms that keep the placenta in place during pregnancy is critical for developing strategies for the prevention of abruption. Failure of physiological transformation of spiral arteries has been described as a major contributing factor of the placental abruption development. Baboons (Papio spp.) share striking similarities with humans in regard to placental structure, utero-placental blood flow, and fetal development; however, the mode of trophoblast invasion is shallow in baboons. This fact prompted the hypothesis that the incidence of placental abruption will be increased in baboons compared to humans. MATERIAL AND METHODS: Baboon placentas were collected between 2002 and 2008. Two independent veterinary pathologists evaluated the slides. A certified physician pathologist performed additional histology. RESULTS: Placental abruption was diagnosed in 22 baboons among 2423 live births during the study period (0.9% prevalence). The most common clinical presentations were fetal demise and vaginal bleeding. The most common pathological findings were intraplacental hemorrhages with or without hematoma formation (86.4%). Other findings consisted of neutrophil infiltration (50%), decidual necrosis (22.7%), decidual vascular congestion and inflammation, villous congestion and retroplacental hemorrhage/hematoma (each 18.2%). These pathologic findings were the same for term and preterm deliveries. CONCLUSION: This is the first systematic study of placental abruption in non-human primates, analyzing a large colony of baboons. Despite differences in trophoblast invasion, the clinical features observed in placental abruption affecting baboons resembled those reported in humans. The cluster of placental pathological findings in baboons also agreed with clinical reports, but the prevalence of these findings differed between baboons and humans. We discuss a mechanism of anti-abruption forces that offset shallow trophoblast invasion observed in baboons. |
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Authors:
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M H Schenone; N Schlabritz-Loutsevitch; J Zhang; J E Samson; G Mari; R J Ferry; G B Hubbard; E J Dick |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-01-21 |
Journal Detail:
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Title: Placenta Volume: 33 ISSN: 1532-3102 ISO Abbreviation: Placenta Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-02-24 Completed Date: 2012-06-28 Revised Date: 2013-05-22 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: 278-84 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN 38103-2896, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abruptio Placentae
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epidemiology,
immunology,
pathology*,
physiopathology* Animals Animals, Laboratory Disease Models, Animal* Female Fetal Death / etiology Hematoma / etiology Hemorrhage / etiology Monkey Diseases / epidemiology, immunology, pathology*, physiopathology* Neutrophil Infiltration Papio* Placenta / blood supply, immunology, pathology Placentation Pregnancy Prevalence Risk Factors Texas Uterine Hemorrhage / etiology |
| Grant Support | |
ID/Acronym/Agency:
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C06 RR014578/RR/NCRR NIH HHS; C06 RR015456/RR/NCRR NIH HHS; C06 RR015456/RR/NCRR NIH HHS; C06RR014578/RR/NCRR NIH HHS; P51 RR013986/RR/NCRR NIH HHS; P51 RR013986/RR/NCRR NIH HHS; R21HD059292/HD/NICHD NIH HHS; U01 DK085465/DK/NIDDK NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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