Document Detail


Abruptio placentae in the baboon (Papio spp.).
MedLine Citation:
PMID:  22265925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Placental abruption is a serious condition that increases perinatal morbidity and mortality. Clinical prevention and treatment options are limited, especially in human preterm deliveries. Knowledge of the mechanisms that keep the placenta in place during pregnancy is critical for developing strategies for the prevention of abruption. Failure of physiological transformation of spiral arteries has been described as a major contributing factor of the placental abruption development. Baboons (Papio spp.) share striking similarities with humans in regard to placental structure, utero-placental blood flow, and fetal development; however, the mode of trophoblast invasion is shallow in baboons. This fact prompted the hypothesis that the incidence of placental abruption will be increased in baboons compared to humans.
MATERIAL AND METHODS: Baboon placentas were collected between 2002 and 2008. Two independent veterinary pathologists evaluated the slides. A certified physician pathologist performed additional histology.
RESULTS: Placental abruption was diagnosed in 22 baboons among 2423 live births during the study period (0.9% prevalence). The most common clinical presentations were fetal demise and vaginal bleeding. The most common pathological findings were intraplacental hemorrhages with or without hematoma formation (86.4%). Other findings consisted of neutrophil infiltration (50%), decidual necrosis (22.7%), decidual vascular congestion and inflammation, villous congestion and retroplacental hemorrhage/hematoma (each 18.2%). These pathologic findings were the same for term and preterm deliveries.
CONCLUSION: This is the first systematic study of placental abruption in non-human primates, analyzing a large colony of baboons. Despite differences in trophoblast invasion, the clinical features observed in placental abruption affecting baboons resembled those reported in humans. The cluster of placental pathological findings in baboons also agreed with clinical reports, but the prevalence of these findings differed between baboons and humans. We discuss a mechanism of anti-abruption forces that offset shallow trophoblast invasion observed in baboons.
Authors:
M H Schenone; N Schlabritz-Loutsevitch; J Zhang; J E Samson; G Mari; R J Ferry; G B Hubbard; E J Dick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-21
Journal Detail:
Title:  Placenta     Volume:  33     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-06-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  278-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN 38103-2896, USA.
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MeSH Terms
Descriptor/Qualifier:
Abruptio Placentae / epidemiology,  immunology,  pathology*,  physiopathology*
Animals
Animals, Laboratory
Disease Models, Animal*
Female
Fetal Death / etiology
Hematoma / etiology
Hemorrhage / etiology
Monkey Diseases / epidemiology,  immunology,  pathology*,  physiopathology*
Neutrophil Infiltration
Papio*
Placenta / blood supply,  immunology,  pathology
Placentation
Pregnancy
Prevalence
Risk Factors
Texas
Uterine Hemorrhage / etiology
Grant Support
ID/Acronym/Agency:
C06 RR014578/RR/NCRR NIH HHS; C06 RR015456/RR/NCRR NIH HHS; C06 RR015456/RR/NCRR NIH HHS; C06RR014578/RR/NCRR NIH HHS; P51 RR013986/RR/NCRR NIH HHS; P51 RR013986/RR/NCRR NIH HHS; R21HD059292/HD/NICHD NIH HHS; U01 DK085465/DK/NIDDK NIH HHS
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