Document Detail


Abruptio placentae associated with misoprostol use in women with preeclampsia.
MedLine Citation:
PMID:  16363752     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate complications associated with cervical ripening with vaginal administration of misoprostol and dinoprostone vaginal inserts in women with preeclampsia. preeclampsia. STUDY DESIGN: Retrospective study of patients with preeclampsia undergoing cervical ripening with vaginal misoprostol and dinoprostone vaginal inserts prior to labor induction. RESULTS: Among 203 patients with preeclampsia undergoing cervical ripening prior to induction, 95 received vaginal misoprostol, and 108 received dinoprostone. The incidence of uterine hyperstimulation requiring medical therapy and the need for emergency cesarean section due tofetal heart rate abnormalities were significantly higher among patients receiving misoprostol (22.1% versus 12.0%, p = 0.04, and 17.9% versus 8.3%, p = 0.03, respectively). The overall incidence of abruptio placentae was 7.4%, with a significantly higher incidence among those receiving misoprostol as compared to dinoprostone (13.7% versus 1.9%, p = 0.001). CONCLUSION: Among patients with preeclampsia undergoing cervical ripening prior to labor induction, there is a higher incidence of acute intrapartum complications (uterine hyperstimulation, cesarean section for fetal heart rate abnormalities and abruptio placentae) with vaginal misoprostol, as compared to dinoprostone, vaginal insert.
Authors:
M Todd Fontenot; David F Lewis; C Brent Barton; Elizabeth M Jones; Jodi A Moore; Arthur T Evans
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  50     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-12-20     Completed Date:  2006-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  653-8     Citation Subset:  IM    
Affiliation:
Florida Perinatal Associates, Tampa, USA. tffpa@aol.com
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MeSH Terms
Descriptor/Qualifier:
Abruptio Placentae / etiology*
Administration, Intravaginal
Adolescent
Adult
Apgar Score
Cervical Ripening / drug effects*
Cesarean Section
Delivery, Obstetric
Dinoprostone / adverse effects*
Female
Heart Rate, Fetal / drug effects
Humans
Infant, Newborn
Labor, Induced
Misoprostol / adverse effects*
Oliguria / etiology
Oxytocics / adverse effects*
Pre-Eclampsia / drug therapy*
Pregnancy
Pregnancy Outcome
Pulmonary Edema / etiology
Retrospective Studies
Chemical
Reg. No./Substance:
0/Oxytocics; 363-24-6/Dinoprostone; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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