Document Detail


Abrupt changes in fibrillatory wave characteristics at the termination of paroxysmal atrial fibrillation in humans.
MedLine Citation:
PMID:  17540663     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: We investigated the process of spontaneous termination of atrial fibrillation (AF) to determine its time course from the surface ECG. METHODS AND RESULTS: We studied fibrillatory waves in Holter recordings of paroxysmal and sustained AF. Following QRS-T cancellation dominant frequencies (DFs) were computed and the relationship of DF to termination was scrutinized. For 57 episodes of paroxysmal AF (PAF) in 24 patients, DF ranged from 4.4 to 6.5 Hz (5.2 +/- 0.4 Hz) compared to 5.8 to 7.4 Hz (6.6 +/- 0.6 Hz) for sustained AF recordings. Comparison of the atrial frequency of the ultimate to the penultimate second demonstrated a drop in frequency in 51 of 57 episodes, P < 0.00001. No comparable change was seen at longer time periods. Moments of comparably low frequency without termination were only occasionally seen in patients with PAF but not in patients with sustained AF. CONCLUSION: Low frequency fibrillation was found to be much more likely to terminate. Frequency changes preceding spontaneous termination were abrupt, in contrast to the gradual frequency drop reported with drug-induced termination. The analysis of fibrillatory wave characteristics and their change over time might be used to target specific moments for pacing therapy in patients with AF.
Authors:
Simona Petrutiu; Alan V Sahakian; Steven Swiryn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-31
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  9     ISSN:  1099-5129     ISO Abbreviation:  Europace     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  466-70     Citation Subset:  IM    
Affiliation:
Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Atrial Fibrillation / physiopathology*
Electrocardiography, Ambulatory*
Female
Fourier Analysis
Humans
Male
Middle Aged
Predictive Value of Tests
Signal Processing, Computer-Assisted

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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