| Abrupt telomere shortening in normal human fibroblasts. | |
| | |
MedLine Citation:
|
PMID: 20080170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Aging is one of the most basic properties of living organisms. Abundant evidence supports the idea that cell senescence underlies organismal aging in higher mammals. Therefore, examining the molecular mechanisms that control cell and replicative senescence is of great interest for biology and medicine. Several discoveries strongly support telomere shortening as the main molecular mechanism that limits the growth of normal cells. Although cultures gradually approach their growth limit, appearance of individual senescent cells is sudden and stochastic. A theoretical model of abrupt telomere shortening has been proposed in order to explain this phenomenon, but until now there was no reliable experimental evidence supporting this idea. Here, we have employed novel methodology to provide evidence for the generation of extrachromosomal circular telomeric DNA as a result of abrupt telomere shortening in normal human fibroblasts. This mechanism ensures heterogeneity in growth potential among individual cells, which is crucial for gradual progression of the aging process. |
| | |
Authors:
|
Nikolina Skrobot Vidacek; Andrea Cukusi?; Milena Ivankovi?; Hrvoje Fulgosi; Miljenko Huzak; James R Smith; Ivica Rubelj |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-18 |
Journal Detail:
|
Title: Experimental gerontology Volume: 45 ISSN: 1873-6815 ISO Abbreviation: Exp. Gerontol. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-22 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
|
Languages: eng Pagination: 235-42 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Molecular Biology, Laboratory of Molecular and Cellular Biology, Ruder Boskovi? Institute, 10000 Zagreb, Croatia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Aging* Cells, Cultured Fibroblasts / ultrastructure* Humans In Situ Hybridization, Fluorescence Microscopy, Electron Telomere* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of Cognitive Function with Serum Uric Acid Level among Chinese Nonagenarians and Centena...
Next Document: Increasing mitochondrial superoxide dismutase abundance leads to impairments in protein quality cont...