| Abrogation of type II collagen-induced arthritis in rats by psychological stress. | |
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MedLine Citation:
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PMID: 575836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study shows that psychological stress, produced either by exposure to a predator or by movement and handling, can profoundly suppress the clinical and histologic manifestations of collagen-induced arthritis. In addition, stress can dissociate the development of humoral and cellular sensitivity to collagen from the occurrence of arthritis. Thus stress modalities provide a means of acquiring additional insights into the pathogenesis of collagen-induced arthritis in rats. Such studies may lead to a further understanding of the relationship between emotional states and the functioning of the immunologic system. This study further illustrates the need to identify and control for the effects of stress in animal studies of immunopathology. Finally, the therapeutic implications of this study for autoimmune diseases would appear self-evident (Fig. 7). |
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Authors:
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M P Rogers; D E Trentham; W J McCune; B I Ginsberg; P Reich; J R David |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Transactions of the Association of American Physicians Volume: 92 ISSN: 0066-9458 ISO Abbreviation: Trans. Assoc. Am. Physicians Publication Date: 1979 |
Date Detail:
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Created Date: 1980-09-23 Completed Date: 1980-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506109 Medline TA: Trans Assoc Am Physicians Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 218-28 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arthritis / therapy* Arthritis, Experimental / psychology, therapy* Autoantibodies / biosynthesis Collagen / administration & dosage, immunology Female Hemagglutination Tests Humans Hypersensitivity, Delayed / chemically induced Radioimmunoassay Rats Stress, Psychological* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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