Document Detail

Abrogation of type II collagen-induced arthritis in rats by psychological stress.
MedLine Citation:
PMID:  575836     Owner:  NLM     Status:  MEDLINE    
This study shows that psychological stress, produced either by exposure to a predator or by movement and handling, can profoundly suppress the clinical and histologic manifestations of collagen-induced arthritis. In addition, stress can dissociate the development of humoral and cellular sensitivity to collagen from the occurrence of arthritis. Thus stress modalities provide a means of acquiring additional insights into the pathogenesis of collagen-induced arthritis in rats. Such studies may lead to a further understanding of the relationship between emotional states and the functioning of the immunologic system. This study further illustrates the need to identify and control for the effects of stress in animal studies of immunopathology. Finally, the therapeutic implications of this study for autoimmune diseases would appear self-evident (Fig. 7).
M P Rogers; D E Trentham; W J McCune; B I Ginsberg; P Reich; J R David
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Transactions of the Association of American Physicians     Volume:  92     ISSN:  0066-9458     ISO Abbreviation:  Trans. Assoc. Am. Physicians     Publication Date:  1979  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506109     Medline TA:  Trans Assoc Am Physicians     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  218-28     Citation Subset:  IM    
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MeSH Terms
Arthritis / therapy*
Arthritis, Experimental / psychology,  therapy*
Autoantibodies / biosynthesis
Collagen / administration & dosage,  immunology
Hemagglutination Tests
Hypersensitivity, Delayed / chemically induced
Stress, Psychological*
Reg. No./Substance:
0/Autoantibodies; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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