Document Detail


Abrogation of thioacetamide-induced biochemical events of hepatic tumor promotion stage by tannic acid in Wistar rats.
MedLine Citation:
PMID:  17725526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tannic acid is present in almost every edible plant and is generally used as a safe food additive. In this study we investigated the antioxidative and antihyperproliferative potential of tannic acid against thioacetoamide (TAA), a potent hepatotoxic-substance-induced oxidative stress and hyperproliferation biomarker. We have shown here that the activities of hepatic antioxidant enzymes, phase II metabolizing enzymes, and the glutathione content were decreased while hepatic ornithine decarboxylase activity and DNA synthesis were induced in TAA-treated animals. Tannic acid administration at two different doses prior to the TAA injection partially recovered the depleted level of glutathione, inhibited activities of antioxidant and phase II metabolizing enzymes, and resulted in significant inhibition of oxidative stress in a dose-dependent manner. Tannic acid administration before TAA treatment also resulted in a significant decrease in ODC activity and [3H]-thymidine incorporation in rat liver, which are classical markers of inflammation and tumor promotion. Our data clearly demonstrate that tannic acid possesses antioxidant and antiproliferating activities because it inhibits early biomarkers of TAA-induced tumor promotion in an in vivo animal model.
Authors:
Anuradha Sehrawat; Sarwat Sultana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer     Volume:  26     ISSN:  0731-8898     ISO Abbreviation:  J. Environ. Pathol. Toxicol. Oncol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-29     Completed Date:  2007-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501420     Medline TA:  J Environ Pathol Toxicol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-20     Citation Subset:  IM    
Affiliation:
Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology
Cell Proliferation / drug effects*
Disease Models, Animal
Dose-Response Relationship, Drug
Glutathione / metabolism
Liver Neoplasms, Experimental / chemically induced,  metabolism*,  pathology
Male
Ornithine Decarboxylase / metabolism
Oxidative Stress / drug effects*
Polyamines / metabolism
Random Allocation
Rats
Rats, Wistar
Tannins / pharmacology*
Thioacetamide
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Polyamines; 0/Tannins; 62-55-5/Thioacetamide; 70-18-8/Glutathione; EC 4.1.1.17/Ornithine Decarboxylase

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