Document Detail


Abrogation of lectin-like oxidized LDL receptor-1 attenuates acute myocardial ischemia-induced renal dysfunction by modulating systemic and local inflammation.
MedLine Citation:
PMID:  22673889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is assumed that acute myocardial infarction affects renal function. To study the mechanism, we used mice following permanent ligation of their left coronary artery that results in extensive myocardial infarction. Soon after ligation, there was a marked rise in circulating pro-inflammatory cytokines and malondialdehyde (thiobarbituric acid-positive evidence of lipid peroxidation). Renal function had significantly declined by the third day in association with mild fibrosis, and swelling of glomeruli and tubules. There was a significant increase in the expression of the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), interelukin-1β, vascular cell adhesion molecule-1, and thiobarbituric acid-reactive substances in the kidney. Renal function showed some recovery by Day 21; however, there was progressive fibrosis of the kidneys. LOX-1 knockout mice had significantly diminished increases in systemic and renal pro-inflammatory cytokines, malondialdehyde, structural alterations, and decline in renal function than the wild-type mice following ligation of the left coronary artery. Cardiac function and survival rates were also significantly better in the LOX-1 knockout mice than in the wild-type mice. Hence, severe myocardial ischemia results in renal dysfunction and histological abnormalities suggestive of acute renal injury. Thus, LOX-1 is a key modulator among multiple mechanisms underlying renal dysfunction following extensive myocardial infarction.
Authors:
Jingjun Lu; Xianwei Wang; Wenze Wang; Harish Muniyappa; Abhishek Deshmukh; Changping Hu; Kumuda Das; Jawahar L Mehta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  82     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-09-27     Completed Date:  2013-10-25     Revised Date:  2014-03-10    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  436-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Collagen / metabolism
Cytokines / blood
Disease Models, Animal
Fibrosis
Glomerular Filtration Rate
Inflammation / etiology,  genetics,  immunology,  metabolism,  pathology,  physiopathology,  prevention & control*
Inflammation Mediators / blood
Kidney / immunology,  metabolism*,  pathology,  physiopathology
Kidney Diseases / etiology,  genetics,  immunology,  metabolism,  pathology,  physiopathology,  prevention & control*
Lipid Peroxidation
Malondialdehyde / metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Myocardial Ischemia / complications*,  genetics,  immunology,  metabolism,  physiopathology
Oxidative Stress
Scavenger Receptors, Class E / deficiency*,  genetics
Time Factors
Grant Support
ID/Acronym/Agency:
R01 HL107885/HL/NHLBI NIH HHS; R01 HL109397/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators; 0/Olr1 protein, mouse; 0/Scavenger Receptors, Class E; 4Y8F71G49Q/Malondialdehyde; 9007-34-5/Collagen

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