Document Detail

Abortifacient efficiency of 15 (S) 15-methyl-prostaglandin F2alpha-methyl ester administered vaginally during early pregnancy.
MedLine Citation:
PMID:  973006     Owner:  NLM     Status:  MEDLINE    
Forty early pregnancies (menses delay 13 - 27 days) were terminated by administering four vaginal suppositoreis each containing 1.0 or 1.5 mg of 15 (S) 15-methyl-prostaglandin F2alpha-methyl ester, one every third hour. In 14 cases serial measurementsof serum estradiol and progesterone were performed during and after therapy. Uterine contractions and bleeding started 1 - 17 hours after administration of the first suppository. Abortion was complete after one week in five women (13%), and after two weeks in 30 (75%). A curettage was performed on eight women, residual placental fragments were found in seven and pregnancy continued in one woman. Mild diarrhoea (65%) and vomiting (40%) were the major side-effects, despite premedication. Estradiol and progesterone levels fell progressively during the therapy. Self-administration of 4 or 6 mg of the methyl ester caused too low a rate of complete abortion for use in practice, but it may be a valuable and practical agent for preoperative dilation of the cervix.
O Ylikorkala; P A Järvinen; M Puukka; L Viinikka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins     Volume:  12     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  609-24     Citation Subset:  IM    
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MeSH Terms
Abortion, Induced*
Drug Evaluation
Estradiol / blood
Pregnancy Trimester, First
Progesterone / blood
Prostaglandins F* / administration & dosage,  pharmacology
Uterine Contraction / drug effects
Reg. No./Substance:
0/Prostaglandins F; 0/Suppositories; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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