Document Detail


Aborted cardiac arrest in a patient carrying KCNE1 D85N variant during the postpartum period.
MedLine Citation:
PMID:  20823649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The postpartum period is associated with an increased risk of fatal ventricular tachyarrhythmias in patients with congenital long QT syndrome (LQTS). We describe a 20-year-old female with LQTS who experienced aborted cardiac arrest during the postpartum period. Genetic screening identified a KCNE1 D85N variant, which has been reported to be a LQTS-causing gene variant, in the patient and her younger sister, whose QT interval was also prolonged. Since the allele frequency of this variant is almost 1%, it may be important to clarify whether such variant carriers indeed have an increased risk of fatal ventricular tachyarrhythmias during the postpartum period.
Authors:
Tadashi Nakajima; Yoshiaki Kaneko; Mamoru Manita; Tatsuya Iso; Masahiko Kurabayashi
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-09-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  49     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-08     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1875-8     Citation Subset:  IM    
Affiliation:
Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Maebashi, Japan. tnakajim@med.gunma-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Alleles
Bradycardia / etiology
Fatal Outcome
Female
Gene Frequency
Genetic Predisposition to Disease
Heart Arrest / etiology*
Humans
Lactation
Long QT Syndrome / complications,  congenital,  genetics*,  physiopathology
Multiple Organ Failure / etiology
Point Mutation*
Potassium Channels, Voltage-Gated / genetics*
Puerperal Disorders / genetics*
Siblings
Tachycardia, Ventricular / etiology
Young Adult
Chemical
Reg. No./Substance:
0/KCNE1 protein, human; 0/Potassium Channels, Voltage-Gated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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