Document Detail


Abnormality of odd-numbered long-chain fatty acids in erythrocyte membrane lipids from patients with disorders of propionate metabolism.
MedLine Citation:
PMID:  2919129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In propionic acidemia and methylmalonic aciduria, disorders of propionate catabolism, excess intracellular propionyl-CoA leads to an enhanced synthesis of odd-numbered long-chain fatty acids. Red cell membrane lipids of patients with these disorders contain pentadecanoic, heptadecanoic, and heptadecenoic acids in excess of normal levels. The odd-numbered long-chain fatty acid content may reflect individual differences in severity of these disorders as well as the degree of effective dietary control. It might be a useful long term parameter for determining the effectiveness of clinical management.
Authors:
U Wendel
Related Documents :
2387779 - Amikacin analogs with a fluorinated amino acid side chain.
24092049 - Periconceptional folic acid associated with an increased risk of oral clefts relative t...
20082149 - An improved method for determining medium- and long-chain fames using gas chromatography.
7159409 - Studies in vitro on shuttle systems of mouse spermatozoa.
952929 - Branched-chain amino acid oxidation by isolated rat tissue preparations.
16658129 - Control and kinetics of branch root formation in cultured root segments of haplopappus ...
6124299 - Phosphonate analogues of acidic amino acids: inhibition of excitatory amino acid transm...
579609 - Oxygen-dependent chemical tumorigenesis in a nicotiana hybrid: inhibition by ascorbic a...
2341809 - 31p nmr of phospholipid glycerol phosphodiester residues.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  25     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-04-06     Completed Date:  1989-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-50     Citation Subset:  IM    
Affiliation:
Kinderklinik, Universität Düsseldorf, Federal Republic of Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Erythrocyte Membrane / analysis*
Fatty Acids / analysis*
Humans
Infant
Infant, Newborn
Malonates / urine*
Membrane Lipids / analysis*
Metabolism, Inborn Errors / blood*
Methylmalonic Acid / urine*
Phosphatidylcholines / analysis
Phosphatidylethanolamines / analysis
Propionates / blood*
Propionic Acids / blood*,  metabolism
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Malonates; 0/Membrane Lipids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Propionates; 0/Propionic Acids; 516-05-2/Methylmalonic Acid; 79-09-4/propionic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vivo mechanical properties of the developing airway.
Next Document:  Galactose metabolism in human ovarian tissue.