Document Detail


Abnormality of odd-numbered long-chain fatty acids in erythrocyte membrane lipids from patients with disorders of propionate metabolism.
MedLine Citation:
PMID:  2919129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In propionic acidemia and methylmalonic aciduria, disorders of propionate catabolism, excess intracellular propionyl-CoA leads to an enhanced synthesis of odd-numbered long-chain fatty acids. Red cell membrane lipids of patients with these disorders contain pentadecanoic, heptadecanoic, and heptadecenoic acids in excess of normal levels. The odd-numbered long-chain fatty acid content may reflect individual differences in severity of these disorders as well as the degree of effective dietary control. It might be a useful long term parameter for determining the effectiveness of clinical management.
Authors:
U Wendel
Related Documents :
3134009 - Acute regulation of the branched-chain 2-oxo acid dehydrogenase complex by adrenaline a...
25402819 - Gas-phase solvation of protonated amino acids by methanol.
23468929 - Investigating acid production by streptococcus mutans with a surface-displayed ph-sensi...
16753609 - The use of organic acids to combat salmonella in poultry: a mechanistic explanation of ...
23454829 - Tissue distribution and identification of radioactivity components at elimination phase...
3778479 - Evidence for direct binding of clostridium botulinum type e derivative toxin and its fr...
11971679 - Posttranslational alanine trans-stimulation of zwitterionic amino acid transport system...
11520869 - Auxin herbicides induce h(2)o(2) overproduction and tissue damage in cleavers (galium a...
25114339 - Efficacy of pink guava pulp as an antioxidant in raw pork emulsion.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  25     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-04-06     Completed Date:  1989-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-50     Citation Subset:  IM    
Affiliation:
Kinderklinik, Universität Düsseldorf, Federal Republic of Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Erythrocyte Membrane / analysis*
Fatty Acids / analysis*
Humans
Infant
Infant, Newborn
Malonates / urine*
Membrane Lipids / analysis*
Metabolism, Inborn Errors / blood*
Methylmalonic Acid / urine*
Phosphatidylcholines / analysis
Phosphatidylethanolamines / analysis
Propionates / blood*
Propionic Acids / blood*,  metabolism
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Malonates; 0/Membrane Lipids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Propionates; 0/Propionic Acids; 516-05-2/Methylmalonic Acid; 79-09-4/propionic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vivo mechanical properties of the developing airway.
Next Document:  Galactose metabolism in human ovarian tissue.