Document Detail

Abnormality of the contralateral ligament after injuries of the medial collateral ligament. An experimental study in rabbits.
MedLine Citation:
PMID:  8126046     Owner:  NLM     Status:  MEDLINE    
The right medial collateral ligament of ninety-four adult, female rabbits was transected operatively. At three, six, fourteen, or forty weeks after the operation, the uninjured, contralateral (left) medial collateral ligaments of seventy-eight of the animals were tested biomechanically and compared with the left medial collateral ligaments of thirty-three normal female rabbits. The diameters of the mid-substance collagen fibrils in the medial collateral ligaments were also measured in the uninjured, contralateral hindlimbs of four animals at each interval and compared with the fibril diameters in three normal animals at each of three corresponding intervals. Subtle but significant differences between the uninjured, contralateral and the normal medial collateral ligaments with regard to biomechanical properties of collagen fibril diameters were found at all time-intervals. These results support the notion of a significant effect on the contralateral ligament after an injury to the medial collateral ligament and suggest that contralateral ligaments cannot be considered as a normal control group even in this relatively benign model of knee injury.
C B Frank; B Loitz; R Bray; D Chimich; G King; N Shrive
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of bone and joint surgery. American volume     Volume:  76     ISSN:  0021-9355     ISO Abbreviation:  J Bone Joint Surg Am     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-04-08     Completed Date:  1994-04-08     Revised Date:  2010-10-25    
Medline Journal Info:
Nlm Unique ID:  0014030     Medline TA:  J Bone Joint Surg Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  403-12     Citation Subset:  AIM; IM    
University of Calgary, Alberta, Canada.
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MeSH Terms
Analysis of Variance
Collagen / ultrastructure
Discriminant Analysis
Disease Models, Animal
Hindlimb / injuries,  physiopathology
Knee Injuries / physiopathology*
Medial Collateral Ligament, Knee / injuries*,  physiopathology*
Multivariate Analysis
Research Design
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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