Document Detail


Abnormalities of von Willebrand factor in myeloproliferative disease: a relationship with bleeding diathesis.
MedLine Citation:
PMID:  3085704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied factor VIII related properties in 24 patients with increased platelet number. Twenty-one were affected by myeloproliferative disorders (eight had polycythaemia vera, 13 had essential thrombocythaemia) and three had secondary thrombocytosis. Normal levels of VIII:C and VIIIR:Ag were found while a significant (P less than 0.05) decrease of VIIIR:RCOF (43 +/- 13%) related to a lack of larger multimers of VWF (39 +/- 12%) was observed in 57% of patients with myeloproliferative disorders. A normal VWF pattern was found in the three patients with secondary thrombocytosis. The highest incidence of VWF abnormalities occurred in patients with essential thrombocythaemia (70%) in comparison with polycythaemic patients (38%). A significant (P less than 0.03) correlation between platelet count and the values of both VIIIR:RCOF and VWF multimeric pattern was observed only in patients with polycythaemia vera. The lowest levels of VIIIR:RCOF and the greatest loss of larger VWF multimers (less than 30%) were observed in two patients who presented bleeding symptoms at the time of study and a prolonged bleeding time. In addition, the relationship between VWF pattern and bleeding diathesis was supported by the fact that 75% of the patients with VWF abnormalities had bleeding history.
Authors:
F Fabris; A Casonato; M Grazia del Ben; L De Marco; A Girolami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  63     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-07-10     Completed Date:  1986-07-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  75-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antigens / analysis
Bleeding Time
Factor VIII / analysis,  immunology
Female
Hemorrhagic Disorders / blood*,  etiology
Humans
Male
Middle Aged
Myeloproliferative Disorders / blood*,  complications
Platelet Count
Polycythemia Vera / blood
Thrombocythemia, Essential / blood
von Willebrand Factor / analysis*
Chemical
Reg. No./Substance:
0/Antigens; 0/von Willebrand Factor; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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