Document Detail

Abnormalities of the retinal cone system in retinitis pigmentosa.
MedLine Citation:
PMID:  8759470     Owner:  NLM     Status:  MEDLINE    
Patients with retinitis pigmentosa (RP) show delayed inner retinal responses as measured by the cone ERG response to a 30 Hz stimulus. To determine the extent to which this delay results from abnormalities of cone phototransduction, cone ERGs to single flashes were obtained from 21 patients with RP and a model of cone phototransduction was fitted to the leading edge of the a-waves of these ERGs. Nearly all patients showed an abnormally low sensitivity of cone phototransduction consistent with a reduction in the amplification of transduction. This abnormality can account for part of the delayed 30 Hz response. Analysis of post-receptoral potentials indicated that RP also slows the responses of the inner retina. A combination of these two factors, a sensitivity change at the receptor and a delay in the response of the inner retina, produces the delayed response of the cone flicker ERG in patients with RP.
D C Hood; D G Birch
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Vision research     Volume:  36     ISSN:  0042-6989     ISO Abbreviation:  Vision Res.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-10-03     Completed Date:  1996-10-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0417402     Medline TA:  Vision Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1699-709     Citation Subset:  IM    
Department of Psychology, Columbia University, New York, NY 10027, USA.
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MeSH Terms
Adaptation, Ocular
Models, Biological
Photic Stimulation
Retinal Cone Photoreceptor Cells / physiopathology*
Retinitis Pigmentosa / physiopathology*
Time Factors
Grant Support
R01-EY-02115/EY/NEI NIH HHS; R01-EY-05235/EY/NEI NIH HHS; R01-EY-09076/EY/NEI NIH HHS

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