| Abnormalities of rate-corrected QT intervals in Parkinson's disease-a comparison with multiple system atrophy and progressive supranuclear palsy. | |
| | |
MedLine Citation:
|
PMID: 12084439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A number of patients with Parkinson's disease (PD) and multiple system atrophy (MSA), in whom sudden death does occur occasionally, have QT or rate-corrected QT (QTc) interval prolongation on electrocardiogram (ECG). Although these QT or QTc interval abnormalities are likely related to autonomic dysfunction, the pathophysiology remains unknown. The aim of this study was to compare the degree of QTc interval prolongation among akinetic-rigid syndromes, namely PD and related disorders, and to evaluate the relationship between QTc prolongation and severity of autonomic dysfunction. Thirty-four patients with PD, 22 with MSA, 11 with progressive supranuclear palsy (PSP) and 30 healthy controls underwent standard autonomic function tests, and electrocardiography variables (RR, QT and QTc intervals) were measured by an ECG recorder with an automated analyzer. The relationship between QTc interval and cardiovascular reflex tests were also analyzed. Orthostatic hypotension and decreased heart rate in response to respiratory stimuli were prominent in MSA, while these were relatively mild in PD. Unlike the RR and QT intervals, the QTc interval significantly differed among all groups (p<0.01). The QTc interval was significantly prolonged in PD (409+/-17 ms; p<0.001) and MSA (404+/-14 ms; p<0.05) compared with healthy controls (394+/-19 ms). Neither autonomic dysfunction nor QTc interval prolongation was evident in PSP. QTc intervals and cardiovascular reflexes did not correlate, except for Valsalva ratio. The QTc interval was obviously prolonged in PD patients to an extent that could not be accounted for simply by autonomic dysfunction levels. MSA patients showed slightly prolonged QTc intervals in spite of marked cardiovascular autonomic dysfunction. Abnormalities of the QTc may reflect the degeneration of cardioselective sympathetic and parasympathetic neurons that cannot be fully captured by cardiovascular autonomic function tests. |
| | |
Authors:
|
Kazushi Deguchi; Iwao Sasaki; Masago Tsukaguchi; Masashi Kamoda; Tetsuo Touge; Hiroaki Takeuchi; Shigeki Kuriyama |
Related Documents
:
|
6218739 - Myocardial mechanics of athletic hearts in comparison with diseased hearts. 7298049 - Drug related myocarditis. i. hypersensitivity myocarditis. 10378019 - Adenoviruses and enteroviruses as pathogens in myocarditis and dilated cardiomyopathy. 3706169 - Electrocardiographic criteria for tricyclic antidepressant cardiotoxicity. 7409609 - Electrocardiographic manifestations in patients with uterine myoma. 9217919 - Prolongation of the qtc interval during alcohol withdrawal syndrome. 20035359 - 3d postural balance with regard to gravity line: an evaluation in the transversal plane... 21808219 - Independent validation of the secondary intracerebral hemorrhage score with catheter an... 6484119 - Renal function during lithium treatment. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Journal of the neurological sciences Volume: 199 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 2002 Jul |
Date Detail:
|
Created Date: 2002-06-26 Completed Date: 2002-08-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 31-7 Citation Subset: IM |
Affiliation:
|
Third Department of Internal Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Autonomic Nervous System / physiopathology Autonomic Nervous System Diseases / complications, diagnosis*, physiopathology Blood Pressure Electrocardiography Female Heart Function Tests Heart Rate Humans Hypotension, Orthostatic / complications, diagnosis, physiopathology Long QT Syndrome / complications, diagnosis*, physiopathology Male Middle Aged Multiple System Atrophy / complications, physiopathology* Parkinson Disease / complications, physiopathology* Reference Values Reflex, Abnormal Supranuclear Palsy, Progressive / physiopathology* Valsalva Maneuver |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association between genetic polymorphism of angiotensin-converting enzyme gene and Parkinson's disea...
Next Document: Signaling pathway for radiation-induced apoptosis in the lymphoblasts from neuronopathic (type A) an...