| Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats. | |
MedLine Citation:
|
PMID: 12865257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Rats selectively bred to develop diet-induced obesity (DIO) spontaneously gain more body weight between 5 and 7 wk of age than do those bred to be diet resistant (DR). Here, chow-fed DIO rats ate 9% more and gained 19% more body weight from 5 to 6 wk of age than did DR rats but had comparable leptin and insulin levels. However, 6-wk-old DIO rats had 29% lower plasma ghrelin levels at dark onset but equivalent levels 6 h later compared with DR rats. When subsequently fed a high-energy (HE; 31% fat) diet for 10 days, DIO rats ate 70% more, gained more body and adipose depot weight, had higher leptin and insulin levels, and had 22% lower feed efficiency than DR rats fed HE diet. In DIO rats on HE diet, leptin levels increased significantly at 3 days followed by increased insulin levels at 7 days. These altered DIO leptin and ghrelin responses were associated with 10% lower leptin receptor mRNA expression in the arcuate (ARC), dorsomedial (DMN), and ventromedial hypothalamic nuclei and 13 and 15% lower ghrelin receptor (GHS-R) mRNA expression in the ARC and DMN than in the DR rats. These data suggest that increased ghrelin signaling is not a proximate cause of DIO, whereas reduced leptin sensitivity might play a causal role. |
Authors:
|
Barry E Levin; Ambrose A Dunn-Meynell; Matt R Ricci; David E Cummings |
Related Documents
:
|
15531717 - Characterization of the resistance to the anorectic and endocrine effects of leptin in ... 18761337 - Dissociation of antihyperglycaemic and adverse effects of partial perioxisome prolifera... 11187927 - Dietary fat intake, supplements, and weight loss. 17033017 - Developmental and nutritional regulation of the prepubertal bovine mammary gland: ii. e... 17249687 - Application of gas chromatography-mass spectrometry metabolite profiling techniques to ... 23798527 - The effects of diet form and feeder design on the growth performance of finishing pigs. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Date: 2003-07-15 |
Journal Detail:
|
Title: American journal of physiology. Endocrinology and metabolism Volume: 285 ISSN: 0193-1849 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2003 Nov |
Date Detail:
|
Created Date: 2003-10-09 Completed Date: 2003-11-20 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
|
Languages: eng Pagination: E949-57 Citation Subset: IM |
Affiliation:
|
Neurology Service, Department of Veterans Affairs Medical Center, 127C VA Medical Center, 385 Tremont Ave., E. Orange, NJ 07018-1095, USA. levin@umdnj.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
anatomy & histology Animals Arcuate Nucleus / chemistry Body Weight Diet Dietary Fats / administration & dosage Dorsomedial Hypothalamic Nucleus / chemistry Eating Energy Intake Ghrelin Insulin / blood Leptin / blood* Male Obesity / blood, etiology*, genetics Organ Size Peptide Hormones / blood* RNA, Messenger / analysis Rats Rats, Sprague-Dawley Receptors, Cell Surface / genetics Receptors, G-Protein-Coupled / genetics Receptors, Ghrelin Receptors, Leptin Signal Transduction Ventromedial Hypothalamic Nucleus / chemistry |
| Grant Support | |
ID/Acronym/Agency:
|
DK-61516/DK/NIDDK NIH HHS; F32 DK-59682/DK/NIDDK NIH HHS; R01 DK-30066/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Ghrelin; 0/Leptin; 0/Peptide Hormones; 0/RNA, Messenger; 0/Receptors, Cell Surface; 0/Receptors, G-Protein-Coupled; 0/Receptors, Ghrelin; 0/Receptors, Leptin; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The interrelationship between TGF-beta1 and nitric oxide is altered in salt-sensitive hypertension.
Next Document: Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mi...