Document Detail


Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats.
MedLine Citation:
PMID:  12865257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats selectively bred to develop diet-induced obesity (DIO) spontaneously gain more body weight between 5 and 7 wk of age than do those bred to be diet resistant (DR). Here, chow-fed DIO rats ate 9% more and gained 19% more body weight from 5 to 6 wk of age than did DR rats but had comparable leptin and insulin levels. However, 6-wk-old DIO rats had 29% lower plasma ghrelin levels at dark onset but equivalent levels 6 h later compared with DR rats. When subsequently fed a high-energy (HE; 31% fat) diet for 10 days, DIO rats ate 70% more, gained more body and adipose depot weight, had higher leptin and insulin levels, and had 22% lower feed efficiency than DR rats fed HE diet. In DIO rats on HE diet, leptin levels increased significantly at 3 days followed by increased insulin levels at 7 days. These altered DIO leptin and ghrelin responses were associated with 10% lower leptin receptor mRNA expression in the arcuate (ARC), dorsomedial (DMN), and ventromedial hypothalamic nuclei and 13 and 15% lower ghrelin receptor (GHS-R) mRNA expression in the ARC and DMN than in the DR rats. These data suggest that increased ghrelin signaling is not a proximate cause of DIO, whereas reduced leptin sensitivity might play a causal role.
Authors:
Barry E Levin; Ambrose A Dunn-Meynell; Matt R Ricci; David E Cummings
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2003-07-15
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  285     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-09     Completed Date:  2003-11-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E949-57     Citation Subset:  IM    
Affiliation:
Neurology Service, Department of Veterans Affairs Medical Center, 127C VA Medical Center, 385 Tremont Ave., E. Orange, NJ 07018-1095, USA. levin@umdnj.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology
Animals
Arcuate Nucleus / chemistry
Body Weight
Diet
Dietary Fats / administration & dosage
Dorsomedial Hypothalamic Nucleus / chemistry
Eating
Energy Intake
Ghrelin
Insulin / blood
Leptin / blood*
Male
Obesity / blood,  etiology*,  genetics
Organ Size
Peptide Hormones / blood*
RNA, Messenger / analysis
Rats
Rats, Sprague-Dawley
Receptors, Cell Surface / genetics
Receptors, G-Protein-Coupled / genetics
Receptors, Ghrelin
Receptors, Leptin
Signal Transduction
Ventromedial Hypothalamic Nucleus / chemistry
Grant Support
ID/Acronym/Agency:
DK-61516/DK/NIDDK NIH HHS; F32 DK-59682/DK/NIDDK NIH HHS; R01 DK-30066/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Ghrelin; 0/Leptin; 0/Peptide Hormones; 0/RNA, Messenger; 0/Receptors, Cell Surface; 0/Receptors, G-Protein-Coupled; 0/Receptors, Ghrelin; 0/Receptors, Leptin; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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