Document Detail


Abnormalities involving chromosome 6 in newly diagnosed patients with non-Hodgkin's lymphoma. Nebraska Lymphoma Study Group.
MedLine Citation:
PMID:  2357689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several cytogenetic abnormalities involving chromosome 6 occurring in non-Hodgkin's lymphoma (NHL) have been described. We report 34 newly diagnosed patients with NHL who had an abnormal chromosome 6 on initial biopsy. Monosomies (n = 5), trisomies (n = 6), deletions of 6q (n = 13), and isochromosomes 6p (n = 9) were frequently observed and translocations were rare. As compared with 70 other NHL patients with cytogenetic abnormalities, the patients with an abnormal chromosome 6 had a higher frequency of immunoblastic lymphoma (p less than 0.001). These patients also were more likely to have B symptoms (p = 0.02). Patients with a breakpoint at 6q11-16 all had a deletion of the distal portion and also were more likely to have B symptoms (p less than 0.001). Most patients with breakpoints at 6q21-25 had a deletion associated with a lower frequency of stage IV disease (p = 0.03) and a higher complete remission (CR) rate (p = 0.03). The patients with an i(6p) had a lower frequency of stage IV disease (p = 0.03), and the patients with a trisomy 6 had a shorter median survival (p = 0.005). Our results suggest that chromosome 6, especially the long arm, carries important information for the clinical behavior of NHL. Future studies are necessary to resolve the molecular defects.
Authors:
H C Schouten; W G Sanger; D D Weisenburger; J O Armitage
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  47     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-07-31     Completed Date:  1990-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  73-82     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University Hospital Maastricht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Chromosome Aberrations*
Chromosomes, Human, Pair 6*
Female
Genetic Markers
Humans
Karyotyping
Lymphoma, Non-Hodgkin / genetics*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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