Document Detail

Abnormalities in carbohydrate and lipid metabolisms in high-fructose dietfed insulin-resistant rats: amelioration by Catharanthus roseus treatments.
MedLine Citation:
PMID:  23334857     Owner:  NLM     Status:  Publisher    
High intake of dietary fructose has been shown to exert a number of adverse metabolic effects in humans and experimental animals. The present study was proposed to elucidate the effect of Catharanthus roseus (C. roseus) leaf powder treatment on alterations in carbohydrate and lipid metabolisms in rats fed with high-fructose diet. Male Wistar rats of body weight around 180 g were divided into four groups, two of these groups (groups C and C+CR) were fed with standard pellet diet and the other two groups (groups F and F+CR) were fed with high-fructose (66 %) diet. C. roseus leaf powder suspension in water (100 mg/kg body weight/day) was administered orally to group C+CR and group F+CR. At the end of a 60-day experimental period, biochemical parameters related to carbohydrate and lipid metabolisms were assayed. C. roseus treatment completely prevented the fructose-induced increased body weight, hyperglycemia, and hypertriglyceridemia. Hyperinsulinemia and insulin resistance observed in group F was significantly decreased with C. roseus treatment in group F+CR. The alterations observed in the activities of enzymes of carbohydrate and lipid metabolisms and contents of hepatic tissue lipids in group F rats were significantly restored to near normal values by C. roseus treatment in group F+CR. In conclusion, our study demonstrates that C. roseus treatment is effective in preventing fructose-induced insulin resistance and hypertriglyceridemia while attenuating the fructose-induced alterations in carbohydrate and lipid metabolisms. This study suggests that the plant can be used as an adjuvant for the prevention and/or management of insulin resistance and disorders related to it.
Karuna Rasineni; Ramesh Bellamkonda; Sreenivasa Reddy Singareddy; Saralakumari Desireddy
Related Documents :
24593787 - Comparison of the effects of escitalopram and atorvastatin on diet-induced atherosclero...
24863087 - Hypercholesterolemic diet induces hepatic steatosis and alterations in mrna expression ...
11182307 - Performance of west african dwarf goats fed guinea grass-verano stylo mixture, n-fertil...
23753417 - Oral formulation of angiotensin-(1-7) improves lipid metabolism and prevents high-fat d...
6313587 - A study of the relationship between performance and dietary component digestibilities b...
3859337 - Inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity and sterol synth...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Journal of physiology and biochemistry     Volume:  -     ISSN:  1877-8755     ISO Abbreviation:  J. Physiol. Biochem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812509     Medline TA:  J Physiol Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515 003, Andhra Pradesh, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Shifting to a control diet after a high-fat, high-sucrose diet intake induces epigenetic changes in ...
Next Document:  The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Pola...