| Abnormalities in mitochondrial structure in cells from patients with bipolar disorder. | |
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MedLine Citation:
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PMID: 20566748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postmortem, genetic, brain imaging, and peripheral cell studies all support decreased mitochondrial activity as a factor in the manifestation of Bipolar Disorder (BD). Because abnormal mitochondrial morphology is often linked to altered energy metabolism, we investigated whether changes in mitochondrial structure were present in brain and peripheral cells of patients with BD. Mitochondria from patients with BD exhibited size and distributional abnormalities compared with psychiatrically-healthy age-matched controls. Specifically, in brain, individual mitochondria profiles had significantly smaller areas, on average, in BD samples (P = 0.03). In peripheral cells, mitochondria in BD samples were concentrated proportionately more within the perinuclear region than in distal processes (P = 0.0008). These mitochondrial changes did not appear to be correlated with exposure to lithium. Also, these abnormalities in brain and peripheral cells were independent of substantial changes in the actin or tubulin cytoskeleton with which mitochondria interact. The observed changes in mitochondrial size and distribution may be linked to energy deficits and, therefore, may have consequences for cell plasticity, resilience, and survival in patients with BD, especially in brain, which has a high-energy requirement. The findings may have implications for diagnosis, if they are specific to BD, and for treatment, if they provide clues as to the underlying pathophysiology of BD. |
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Authors:
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Anne M Cataldo; Donna L McPhie; Nicholas T Lange; Steven Punzell; Sarah Elmiligy; Nancy Z Ye; Michael P Froimowitz; Linda C Hassinger; Emily B Menesale; Laura W Sargent; David J Logan; Anne E Carpenter; Bruce M Cohen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-21 |
Journal Detail:
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Title: The American journal of pathology Volume: 177 ISSN: 1525-2191 ISO Abbreviation: Am. J. Pathol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2011-01-25 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 575-85 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Adult Aged Aged, 80 and over Antidepressive Agents / pharmacology Bipolar Disorder / pathology* Cell Line Cytochromes c / metabolism Cytoskeleton / ultrastructure Energy Metabolism Female Fibroblasts / drug effects, ultrastructure Humans Lithium Carbonate / pharmacology Male Middle Aged Mitochondria / pathology*, ultrastructure Prefrontal Cortex* / cytology, metabolism Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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MH60450/MH/NIMH NIH HHS; NS37483/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 554-13-2/Lithium Carbonate; 56-65-5/Adenosine Triphosphate; 9007-43-6/Cytochromes c |
| Comments/Corrections | |
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