Document Detail

Abnormalities in Fatty acids in plasma, erythrocytes and adipose tissue in Japanese patients with colorectal cancer.
MedLine Citation:
PMID:  23422479     Owner:  NLM     Status:  In-Data-Review    
MATERIALS AND METHODS: In the present study we investigated the fatty acid composition in plasma, red blood cells (RBCs) and adipose tissue from Japanese patients with colorectal cancer, or benign disease.
RESULTS: Sixty-one patients with histologically-confirmed colorectal cancer and 42 patients with non-malignant disease were recruited for this study. The fatty acid composition of the total phospholipid (PL) fraction of plasma and washed RBCs was determined by gas chromatography. The fatty acid composition of the triacylglycerol (TAG) fraction of subcutaneous adipose tissue was determined in a similar manner. The EPA proportion in the plasma and RBC PL fractions was significantly lower in patients with cancer than in the controls (p<0.05). Similarly, the LNA proportion in the RBC PL fraction was lower in patients with cancer, but no changes were found in the plasma PL fraction. Arachidonic acid was the only PUFA in the adipose TAG fraction that exhibited significant differences, with higher levels in the patients with cancer than in the controls.
CONCLUSION: Our findings suggest that patients with cancer have abnormalities in PUFAs in the plasma PL, erythrocyte PL, and adipose TAG fractions. Further investigation is needed to clarify the differences in the results between the various fractions.
Masashi Okuno; Kei Hamazaki; Tokuhiro Ogura; Hiroaki Kitade; Takashi Matsuura; Ryo Yoshida; Takashi Hijikawa; Masanori Kwon; Seizaburo Arita; Miho Itomura; Tomohito Hamazaki; Hideho Takada
Related Documents :
16666969 - Regulatory structure of the biosynthetic pathway for the aspartate family of amino acid...
7057189 - Regional blood-brain barrier permeability to amino acids after portacaval anastomosis.
17030339 - Partial molar volumes of proteins: amino acid side-chain contributions derived from the...
23077309 - A single-amino-acid change in murine norovirus ns1/2 is sufficient for colonic tropism ...
1730059 - Differential mechanisms of induction of ornithine decarboxylase in rat intestine by l- ...
23577989 - Physiological assessment of epithelial function in damaged rat colon.
25332139 - Physicochemical and nutritional characteristics of preserved duck egg white.
16668249 - Mechanism of aluminum tolerance in snapbeans : root exudation of citric acid.
15885939 - Impurity formation studies with peptide-loaded polymeric microspheres part ii. in vitro...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  27     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  IM    
Division of Surgery, Takii Hospital of Kansai Medical University, 10-15 Fumizono, Moriguchi City, Osaka 570-8507, Japan
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical Experience of Treatment of Metastatic Melanoma and Solid Tumours Adopting a Derivative of D...
Next Document:  Cytogenetic abnormalities in follicular dendritic cell sarcoma: report of two cases and literature r...