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Abnormalities in Fatty acids in plasma, erythrocytes and adipose tissue in Japanese patients with colorectal cancer.
MedLine Citation:
PMID:  23422479     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MATERIALS AND METHODS: In the present study we investigated the fatty acid composition in plasma, red blood cells (RBCs) and adipose tissue from Japanese patients with colorectal cancer, or benign disease.
RESULTS: Sixty-one patients with histologically-confirmed colorectal cancer and 42 patients with non-malignant disease were recruited for this study. The fatty acid composition of the total phospholipid (PL) fraction of plasma and washed RBCs was determined by gas chromatography. The fatty acid composition of the triacylglycerol (TAG) fraction of subcutaneous adipose tissue was determined in a similar manner. The EPA proportion in the plasma and RBC PL fractions was significantly lower in patients with cancer than in the controls (p<0.05). Similarly, the LNA proportion in the RBC PL fraction was lower in patients with cancer, but no changes were found in the plasma PL fraction. Arachidonic acid was the only PUFA in the adipose TAG fraction that exhibited significant differences, with higher levels in the patients with cancer than in the controls.
CONCLUSION: Our findings suggest that patients with cancer have abnormalities in PUFAs in the plasma PL, erythrocyte PL, and adipose TAG fractions. Further investigation is needed to clarify the differences in the results between the various fractions.
Authors:
Masashi Okuno; Kei Hamazaki; Tokuhiro Ogura; Hiroaki Kitade; Takashi Matsuura; Ryo Yoshida; Takashi Hijikawa; Masanori Kwon; Seizaburo Arita; Miho Itomura; Tomohito Hamazaki; Hideho Takada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  27     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  IM    
Affiliation:
Division of Surgery, Takii Hospital of Kansai Medical University, 10-15 Fumizono, Moriguchi City, Osaka 570-8507, Japan takadahi@takii.kmu.ac.jp.
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